换一批Novel GHRH antagonists suppress the growth of human malignant melanoma by restoring nuclear p27 function.
第一作者：
Luca,Szalontay
第一单位：
a Veterans Affairs Medical Center and South Florida Veterans Affairs Foundation for Research and Education ; Miami , FL USA.
作者：
关键词
ANOVA, one-way analysis of varianceAbu, a-aminobutyric acidAc, acetylAda, 12-aminododecanoylAgm, agmatineAmc, 8-aminocaprylylCpa, parachlorophenylalanineFBS, fetal bovine serumFpa5, pentafluoro-phenylalanineGH, growth hormoneGHRH, growth hormone-releasing hormoneGHRH-R, growth hormone-releasing hormone receptorHar, homoarginineIGF-I, insulin-like growth factor IMTS, 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfonphenyl)-2H-tetrazoliumNle, norleucineOrn, ornithinePh, phenylPhAc, phenylacetylSVs, splice variantsTBS, tris-buffered salineTyr(Me), O-methyltyrosinegrowth hormone-releasing hormone antagonisthGHRH, human growth hormone-releasing hormonemTOR, mammalian target of rapamycinmelanomap27pGHRH-R, pituitary type GHRH-receptortargeted therapyxenografted mouse model
医学主题词
动物(Animals);细胞周期(Cell Cycle);细胞系, 肿瘤(Cell Line, Tumor);细胞核(Cell Nucleus);细胞增殖(Cell Proliferation);周期素依赖激酶抑制剂p27(Cyclin-Dependent Kinase Inhibitor p27);女(雌)性(Female);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);生长激素释放激素(Growth Hormone-Releasing Hormone);人类(Humans);黑色素瘤(Melanoma);小鼠, 裸(Mice, Nude);受体, 神经肽(Receptors, Neuropeptide);受体, 垂体激素调节激素(Receptors, Pituitary Hormone-Regulating Hormone);舍莫瑞林(Sermorelin);信号传导(Signal Transduction);皮肤肿瘤(Skin Neoplasms);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.4161/15384101.2015.945879
PMID
25486366
发布时间
2023-12-13
- 浏览18
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文
