p53-dependent activation of microRNA-34a in response to etoposide-induced DNA damage in osteosarcoma cell lines not impaired by dominant negative p53 expression.
第一作者:
Chiara,Novello
第一单位:
Laboratory of Experimental Oncology, Rizzoli Orthopaedic Institute, Bologna, Italy.
作者:
医学主题词
抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);碱基序列(Base Sequence);印迹法, 蛋白质(Blotting, Western);骨肿瘤(Bone Neoplasms);细胞周期(Cell Cycle);细胞增殖(Cell Proliferation);染色质免疫沉淀法(Chromatin Immunoprecipitation);DNA损伤(DNA Damage);DNA甲基化(DNA Methylation);依托泊甙(Etoposide);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);基因, 显性(Genes, Dominant);人类(Humans);微RNAs(MicroRNAs);分子序列数据(Molecular Sequence Data);突变(Mutation);骨肉瘤(Osteosarcoma);启动区, 遗传(Promoter Regions, Genetic);RNA, 信使(RNA, Messenger);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction);序列同源性, 核酸(Sequence Homology, Nucleic Acid);肿瘤细胞, 培养的(Tumor Cells, Cultured);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53)
DOI
10.1371/journal.pone.0114757
PMID
25490093
发布时间
2018-11-13
- 浏览15
PloS one
e114757页
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