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The systemic delivery of an oncolytic adenovirus expressing decorin inhibits bone metastasis in a mouse model of human prostate cancer.

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第一作者： W,Xu

第一单位： Gene Therapy Program, Department of Medicine, NorthShore Research Institute, an affiliate of the University of Chicago, Evanston, IL, USA.

作者： W,Xu ^[1] ; T,Neill ^[2] ; Y,Yang ^[1] ; Z,Hu ^[3] ; E,Cleveland ^[4] ; Y,Wu ^[5] ; R,Hutten ^[5] ; X,Xiao ^[6] ; S R,Stock ^[7] ; D,Shevrin ^[8] ; K,Kaul ^[4] ; C,Brendler ^[9] ; R V,Iozzo ^[2] ; P,Seth ^[1]

作者单位： Gene Therapy Program, Department of Medicine, NorthShore Research Institute, an affiliate of the University of Chicago, Evanston, IL, USA. ^[1] Department of Pathology, Anatomy and Cell Biology and the Cancer Cell Biology and Signaling Program, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA. ^[2] 1st Division of in Vitro Diagnostic Reagents, National Institutes for Food and Drug Control, Beijing, China. ^[3] Department of Pathology, NorthShore Research Institute, Evanston, IL, USA. ^[4] Image processing Lab, Department of Radiology, NorthShore Research Institute, Evanston, IL, USA. ^[5] Advanced Photon Source, Argonne National Lab, Lemont, IL, USA. ^[6] Department of Cell and Molecular Biology, Northwestern University, Chicago, IL, USA. ^[7] Department of Medicine, NorthShore Research Institute, Evanston, USA. ^[8] Department of Surgery, NorthShore University HealthSytem, Evanston, IL, USA. ^[9]

医学主题词动物(Animals);骨肿瘤(Bone Neoplasms);细胞系, 肿瘤(Cell Line, Tumor);细胞运动(Cell Movement);核心蛋白多糖(Decorin);疾病模型, 动物(Disease Models, Animal);基因转移技术(Gene Transfer Techniques);人类(Humans);男(雄)性(Male);小鼠, 裸(Mice, Nude);溶瘤病毒疗法(Oncolytic Virotherapy);溶瘤病毒(Oncolytic Viruses);前列腺肿瘤(Prostatic Neoplasms)

DOI 10.1038/gt.2014.110

PMID 25503693

发布时间 2018-11-13

基金项目

R01 CA039481/CA/NCI NIH HHS/United States R01 CA127380/CA/NCI NIH HHS/United States R01CA12738/CA/NCI NIH HHS/United States R01CA39481/CA/NCI NIH HHS/United States

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