Browning of human adipocytes requires KLF11 and reprogramming of PPARγ superenhancers.

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第一作者： Anne,Loft

第一单位： Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230 Odense M, Denmark;

作者： Anne,Loft ^[1] ; Isabel,Forss ^[1] ; Majken Storm,Siersbæk ^[1] ; Søren Fisker,Schmidt ^[1] ; Ann-Sofie Bøgh,Larsen ^[1] ; Jesper Grud Skat,Madsen ^[2] ; Didier F,Pisani ^[3] ; Ronni,Nielsen ^[1] ; Mads Malik,Aagaard ^[1] ; Angela,Mathison ^[4] ; Matt J,Neville ^[5] ; Raul,Urrutia ^[4] ; Fredrik,Karpe ^[5] ; Ez-Zoubir,Amri ^[3] ; Susanne,Mandrup ^[6]

作者单位： Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230 Odense M, Denmark; ^[1] Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230 Odense M, Denmark; The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, DK-2200 Copenhagen, Denmark; ^[2] UMR 7277, Centre National de la Recherche Scientifique, U1091, Institut National de la Santé et de la Recherche Médicale, Institute of Biology Valrose, University Nice Sophia Antipolis, 06100 Nice, France; ^[3] Laboratory of Epigenetics and Chromatin Dynamics, Mayo Clinic, Rochester, Minnesota 55905, USA; ^[4] National Institute for Health Research, Oxford Biomedical Research Centre, OX3 7LE Oxford, United Kingdom. ^[5] Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230 Odense M, Denmark; s.mandrup@bmb.sdu.dk. ^[6]

关键词 KLF11 PPARγ browning of human adipocytes genomic reprogramming rosiglitazone superenhancer