首页> Pharmacology research & perspectives> The potent and selective α4β2*/α6*-nicotinic acetylcholine receptor partial agonist 2-[5-[5-((S)Azetidin-2-ylmethoxy)-3-pyridinyl]-3-isoxazolyl]ethanol demonstrates antidepressive-like behavior in animal models and a favorable ADME-tox profile.

The potent and selective α4β2/α6-nicotinic acetylcholine receptor partial agonist 2-[5-[5-((S)Azetidin-2-ylmethoxy)-3-pyridinyl]-3-isoxazolyl]ethanol demonstrates antidepressive-like behavior in animal models and a favorable ADME-tox profile.

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第一作者： Li-Fang,Yu

第一单位： Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago 833 South Wood Street, Chicago, Illinois, 60612 ; Institute of Drug Design and Development, Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University 3663 North Zhongshan Road, Shanghai, 200062, China.

作者： Li-Fang,Yu ^[1] ; J,Brek Eaton ^[2] ; Han-Kun,Zhang ^[3] ; Emily,Sabath ^[4] ; Taleen,Hanania ^[4] ; Guan-Nan,Li ^[5] ; Richard B,van Breemen ^[5] ; Paul,Whiteaker ^[2] ; Qiang,Liu ^[6] ; Jie,Wu ^[7] ; Yong-Chang,Chang ^[2] ; Ronald J,Lukas ^[2] ; Dani,Brunner ^[8] ; Alan P,Kozikowski ^[5]

作者单位： Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago 833 South Wood Street, Chicago, Illinois, 60612 ; Institute of Drug Design and Development, Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University 3663 North Zhongshan Road, Shanghai, 200062, China. ^[1] Division of Neurobiology, Barrow Neurological Institute 350 West Thomas Road, Phoenix, Arizona, 85013. ^[2] Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago 833 South Wood Street, Chicago, Illinois, 60612 ; Institute of Biomedical Sciences and School of Life Sciences, East China Normal University 500 Dongchuan Road, Shanghai, 200241, China. ^[3] PsychoGenics, Inc. 765 Old Saw Mill River Road, Tarrytown, New York, 10591. ^[4] Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago 833 South Wood Street, Chicago, Illinois, 60612. ^[5] Division of Neurobiology, Barrow Neurological Institute 350 West Thomas Road, Phoenix, Arizona, 85013 ; Division of Neurology, Barrow Neurological Institute 350 West Thomas Road, Phoenix, Arizona, 85013. ^[6] Division of Neurology, Barrow Neurological Institute 350 West Thomas Road, Phoenix, Arizona, 85013. ^[7] PsychoGenics, Inc. 765 Old Saw Mill River Road, Tarrytown, New York, 10591 ; Department of Psychiatry, Columbia University, NYSPI 1051 Riverside Drive, New York, New York, 10032. ^[8]

关键词 Antidepressive-like behavior nicotinic acetylcholine receptor partial agonist selectivity

DOI 10.1002/prp2.26

PMID 25505580

发布时间 2018-11-13

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Pharmacology research & perspectives

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The potent and selective α4β2/α6-nicotinic acetylcholine receptor partial agonist 2-[5-[5-((S)Azetidin-2-ylmethoxy)-3-pyridinyl]-3-isoxazolyl]ethanol demonstrates antidepressive-like behavior in animal models and a favorable ADME-tox profile.

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The potent and selective α4β2*/α6*-nicotinic acetylcholine receptor partial agonist 2-[5-[5-((S)Azetidin-2-ylmethoxy)-3-pyridinyl]-3-isoxazolyl]ethanol demonstrates antidepressive-like behavior in animal models and a favorable ADME-tox profile.

Pharmacology research & perspectives

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The potent and selective α4β2/α6-nicotinic acetylcholine receptor partial agonist 2-[5-[5-((S)Azetidin-2-ylmethoxy)-3-pyridinyl]-3-isoxazolyl]ethanol demonstrates antidepressive-like behavior in animal models and a favorable ADME-tox profile.