Antitumor activity in RAS-driven tumors by blocking AKT and MEK.-论文-万方医学网

作者： Anthony W,Tolcher ^[1] ; Khurum,Khan ^[2] ; Michael,Ong ^[2] ; Udai,Banerji ^[2] ; Vassiliki,Papadimitrakopoulou ^[3] ; David R,Gandara ^[4] ; Amita,Patnaik ^[1] ; Richard D,Baird ^[2] ; David,Olmos ^[2] ; Christopher R,Garrett ^[3] ; Jeffrey M,Skolnik ^[5] ; Eric H,Rubin ^[6] ; Paul D,Smith ^[5] ; Pearl,Huang ^[6] ; Maria,Learoyd ^[5] ; Keith A,Shannon ^[6] ; Anne,Morosky ^[6] ; Ernestina,Tetteh ^[6] ; Ying-Ming,Jou ^[6] ; Kyriakos P,Papadopoulos ^[1] ; Victor,Moreno ^[2] ; Brianne,Kaiser ^[1] ; Timothy A,Yap ^[2] ; Li,Yan ^[6] ; Johann S,de Bono ^[7]

作者单位： South Texas Accelerated Research Therapeutics, START Center for Cancer Care, San Antonio Texas. ^[1] Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, London, United Kingdom. ^[2] MD Anderson Cancer Center, Houston, Texas. ^[3] UC Davis Cancer Center, Sacramento, California. ^[4] AstraZeneca, Alderley Park, Macclesfield, Cheshire, United Kingdom. ^[5] Merck & Co., Inc., Whitehouse Station, New Jersey. ^[6] Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, London, United Kingdom. johann.de-Bono@icr.ac.uk. ^[7]

主题词成年人(Adult);老年人(Aged);老年人, 80以上(Aged, 80 and over);动物(Animals);抗肿瘤联合化疗方案(Antineoplastic Combined Chemotherapy Protocols);苯咪唑类(Benzimidazoles);细胞系, 肿瘤(Cell Line, Tumor);女(雌)性(Female);杂环化合物, 3环(Heterocyclic Compounds, 3-Ring);人类(Humans);MAP激酶激酶激酶类(MAP Kinase Kinase Kinases);男(雄)性(Male);小鼠(Mice);中年人(Middle Aged);肿瘤(Neoplasms);原癌基因蛋白质类(Proto-Oncogene Proteins);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);原癌基因蛋白质类p21(ras)(Proto-Oncogene Proteins p21(ras));异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays);ras蛋白质类(ras Proteins)

DOI 10.1158/1078-0432.CCR-14-1901

PMID 25516890

发布时间 2024-02-10

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Antitumor activity in RAS-driven tumors by blocking AKT and MEK.

Clinical cancer research

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Clinical cancer research

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Antitumor activity in RAS-driven tumors by blocking AKT and MEK.

Clinical cancer research

相似文献

Clinical cancer research

相关期刊

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