换一批
换一批A novel approach to investigate the effect of methionine oxidation on pharmacokinetic properties of therapeutic antibodies.
第一作者：
Jan,Stracke
第一单位：
a Biochemical and Analytical Research; Large Molecule Research ; Roche Pharma Research and Early Development (pRED); Roche Innovation Center ; Penzberg , Germany.
作者：
关键词
AUC, area under the concentration-time curveAntibodyESI-MS, electrospray ionization mass spectrometryFab, antigen-binding fragmentFc, crystallizable fragmentFcRnFcRn, neonatal Fc receptorHRP, horseradish peroxidaseIgG, immunoglobulin GMet, methionineMet252Met428PK, pharmacokineticRU, response unitsSEC, size exclusion chromatographySPR, surface plasmon resonanceaffinity chromatographycolumndegradationm/z, mass-to-charge ratiomAb, monoclonal antibodymethionine oxidationneonatal Fc receptorpH gradientpharmacokinetics
主题词
动物(Animals);抗体, 单克隆(Antibodies, Monoclonal);抗体亲和力(Antibody Affinity);色谱法, 亲和(Chromatography, Affinity);女(雌)性(Female);组织相容性抗原Ⅰ类(Histocompatibility Antigens Class I);人类(Humans);氢离子浓度(Hydrogen-Ion Concentration);免疫球蛋白Fc片段(Immunoglobulin Fc Fragments);代谢清除率(Metabolic Clearance Rate);甲硫氨酸(Methionine);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);小鼠, 转基因(Mice, Transgenic);氧化还原(Oxidation-Reduction);蛋白质结合(Protein Binding);受体, Fc(Receptors, Fc);光谱法, 质量, 电喷雾电离(Spectrometry, Mass, Electrospray Ionization)
DOI
10.4161/mabs.29601
PMID
25517308
发布时间
2018-12-02
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