换一批A monoclonal antibody against hinge-cleaved IgG restores effector function to proteolytically-inactivated IgGs in vitro and in vivo.
第一作者：
Randall J,Brezski
第一单位：
a Biologics Research, Janssen Research & Development, LLC , Spring House , PA , USA.
作者：
关键词
ADCC, antibody-dependent cell-mediated cytotoxicityCDC, complement-dependent cytotoxicityFACS, fluorescence-activated cell sorterGluV8, glutamyl endopeptidase V8IdeS, Immunoglobulin G-degrading enzyme of Streptococcus pyogenesIgG fragmentsMMP, matrix metalloproteinasePBMC, peripheral blood mononuclear cellantibody-dependent cell-mediated cytotoxicitychimeric antibodycomplement-dependent cytotoxicityhinge regionmAb, monoclonal antibody
医学主题词
动物(Animals);抗体, 单克隆(Antibodies, Monoclonal);抗体, 单克隆, 鼠源性(Antibodies, Monoclonal, Murine-Derived);抗体依赖细胞细胞毒性(Antibody-Dependent Cell Cytotoxicity);细菌蛋白质类(Bacterial Proteins);血小板(Blood Platelets);细胞系(Cell Line);细胞系, 肿瘤(Cell Line, Tumor);半胱氨酸内肽酶类(Cysteine Endopeptidases);狗(Dogs);酶联免疫吸附测定(Enzyme-Linked Immunosorbent Assay);表位(Epitopes);人类(Humans);免疫球蛋白Fab片段(Immunoglobulin Fab Fragments);免疫球蛋白G(Immunoglobulin G);基质金属蛋白酶3(Matrix Metalloproteinase 3);血小板计数(Platelet Count);大鼠(Rats)
DOI
10.4161/mabs.29825
PMID
25517311
发布时间
2021-01-03
- 浏览82
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文
