The Sm protein methyltransferase PRMT5 is not required for primordial germ cell specification in mice.

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作者： Ziwei,Li ^[1] ; Juehua,Yu ^[2] ; Linzi,Hosohama ^[3] ; Kevin,Nee ^[1] ; Sofia,Gkountela ^[1] ; Sonal,Chaudhari ^[3] ; Ashley A,Cass ^[4] ; Xinshu,Xiao ^[4] ; Amander T,Clark ^[5]

作者单位： Department of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA, USA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA, USA. ^[1] David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA. ^[2] Department of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA, USA. ^[3] Bioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, USA Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA. ^[4] Department of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA, USA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA, USA Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA, USA clarka@ucla.edu. ^[5]

关键词 PGC specification PRMT5 conditional knockout germline absence splicing