Structural basis for the disruption of the cerebral cavernous malformations 2 (CCM2) interaction with Krev interaction trapped 1 (KRIT1) by disease-associated mutations.
第一作者:
Oriana S,Fisher
第一单位:
From the Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520.
作者:
医学主题词
载体蛋白质类(Carrier Proteins);色谱法, 凝胶(Chromatography, Gel);血管瘤, 海绵状, 中枢神经系统(Hemangioma, Cavernous, Central Nervous System);人类(Humans);免疫沉淀法(Immunoprecipitation);微管相关蛋白质类(Microtubule-Associated Proteins);突变(Mutation);突变, 误义(Mutation, Missense);点突变(Point Mutation);蛋白质结合(Protein Binding);蛋白质结构, 二级(Protein Structure, Secondary);蛋白质结构, 三级(Protein Structure, Tertiary);原癌基因蛋白质类(Proto-Oncogene Proteins)
DOI
10.1074/jbc.M114.616433
PMID
25525273
发布时间
2021-02-05
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