Structure-activity-relationship study of N-acyl-N-phenylpiperazines as potential inhibitors of the Excitatory Amino Acid Transporters (EAATs): improving the potency of a micromolar screening Hit is not truism.

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第一作者： Tri Hv,Huynh

第一单位： Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, OE 2100 Denmark.

作者： Tri Hv,Huynh ^[1] ; Charles S,Demmer ^[1] ; Bjarke,Abrahamsen ^[1] ; Emil,Marcher ^[1] ; Mikael,Frykman ^[1] ; Anders A,Jensen ^[1] ; Lennart,Bunch ^[1]

作者单位： Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, OE 2100 Denmark. ^[1]

关键词 EAATs Excitatory amino acid transporters Medicinal chemistry Rational ligand design

DOI 10.1186/2193-1801-2-112

PMID 25530930

发布时间 2020-09-30

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Structure-activity-relationship study of N-acyl-N-phenylpiperazines as potential inhibitors of the Excitatory Amino Acid Transporters (EAATs): improving the potency of a micromolar screening Hit is not truism.

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Structure-activity-relationship study of N-acyl-N-phenylpiperazines as potential inhibitors of the Excitatory Amino Acid Transporters (EAATs): improving the potency of a micromolar screening Hit is not truism.

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