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The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling.

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第一作者： Tomoyo,Okada

第一单位： Cell Biology Program, Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

作者： Tomoyo,Okada ^[1] ; Surajit,Sinha ^[1] ; Ilaria,Esposito ^[1] ; Gaia,Schiavon ^[1] ; Miguel A,López-Lago ^[1] ; Wenjing,Su ^[1] ; Christine A,Pratilas ^[2] ; Cristina,Abele ^[3] ; Jonathan M,Hernandez ^[4] ; Masahiro,Ohara ^[5] ; Morihito,Okada ^[5] ; Agnes,Viale ^[6] ; Adriana,Heguy ^[7] ; Nicholas D,Socci ^[8] ; Anna,Sapino ^[9] ; Venkatraman E,Seshan ^[10] ; Stephen,Long ^[11] ; Giorgio,Inghirami ^[3] ; Neal,Rosen ^[12] ; Filippo G,Giancotti ^[1]

作者单位： Cell Biology Program, Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA. ^[1] 1] Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA [2] Department of Pediatrics, Memorial Hospital, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA. ^[2] Department of Biomedical Sciences and Human Oncology, Center of Experimental Medicine and Research, University of Torino, Torino 10126, Italy. ^[3] 1] Cell Biology Program, Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA [2] Department of Surgery, Memorial Hospital, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA. ^[4] Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734-8551, Japan. ^[5] Genomics Core Facility, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA. ^[6] Geoffrey Beene Translational Oncology Core Facility, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA. ^[7] Bioinformatics Core Facility, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA. ^[8] Department of Medical Sciences, Center of Experimental Medicine and Research, University of Torino, Torino 10126, Italy. ^[9] Department of Epidemiology and Biostatistics, Memorial Hospital, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA. ^[10] Structural Biology Program, Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA. ^[11] 1] Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA [2] Department of Medicine, Memorial Hospital, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA. ^[12]

医学主题词动物(Animals);细胞黏附(Cell Adhesion);细胞系, 肿瘤(Cell Line, Tumor);细胞极性(Cell Polarity);细胞增殖(Cell Proliferation);细胞转化, 肿瘤(Cell Transformation, Neoplastic);上皮-间质转化(Epithelial-Mesenchymal Transition);女(雌)性(Female);人类(Humans);肺肿瘤(Lung Neoplasms);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 近交NOD(Mice, Inbred NOD);小鼠, SCID(Mice, SCID);神经组织蛋白质类(Nerve Tissue Proteins);原癌基因蛋白质c-myc(Proto-Oncogene Proteins c-myc);受体, 细胞表面(Receptors, Cell Surface);信号传导(Signal Transduction);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53);p120 GTP酶激活蛋白质(p120 GTPase Activating Protein);rap1 GTP结合蛋白质类(rap1 GTP-Binding Proteins);ras GTP酶激活蛋白质类(ras GTPase-Activating Proteins);ρGTP结合蛋白质类(rho GTP-Binding Proteins)

DOI 10.1038/ncb3082

PMID 25531777

发布时间 2022-03-17

基金项目

T32 CA009501/CA/NCI NIH HHS/United States R01 CA113996/CA/NCI NIH HHS/United States P30 CA08748/CA/NCI NIH HHS/United States P30 CA008748/CA/NCI NIH HHS/United States R01 CA058976/CA/NCI NIH HHS/United States R01 CA078901/CA/NCI NIH HHS/United States P01 CA094060/CA/NCI NIH HHS/United States

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