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Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease.

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第一作者： Xiao-Hong,Lu

第一单位： Center for Neurobehavioral Genetics, Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA. Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. UCLA Brain Research Institute, Los Angeles, CA 90095, USA.

作者： Xiao-Hong,Lu ^[1] ; Virginia B,Mattis ^[2] ; Nan,Wang ^[1] ; Ismael,Al-Ramahi ^[3] ; Nick,van den Berg ^[4] ; Silvina A,Fratantoni ^[4] ; Henry,Waldvogel ^[5] ; Erin,Greiner ^[1] ; Alex,Osmand ^[6] ; Karla,Elzein ^[3] ; Jingbo,Xiao ^[7] ; Sipke,Dijkstra ^[4] ; Remko,de Pril ^[8] ; Harry V,Vinters ^[9] ; Richard,Faull ^[5] ; Ethan,Signer ^[10] ; Seung,Kwak ^[10] ; Juan J,Marugan ^[7] ; Juan,Botas ^[3] ; David F,Fischer ^[4] ; Clive N,Svendsen ^[2] ; Ignacio,Munoz-Sanjuan ^[10] ; X William,Yang ^[11]

作者单位： Center for Neurobehavioral Genetics, Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA. Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. UCLA Brain Research Institute, Los Angeles, CA 90095, USA. ^[1] Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. ^[2] Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA. Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA. ^[3] BioFocus, a Charles River company, Leiden 233CR, the Netherlands. ^[4] Department of Anatomy with Radiology, Centre for Brain Research, Faculty of Medical and Health Sciences, The University of Auckland, Auckland 1023, New Zealand. ^[5] Department of Biochemistry and Cellular and Molecular Biology, Knoxville, TN 37996, USA. ^[6] NIH Chemical Genomic Center, National Center for Advancing Translation Sciences, National Institutes of Health, Rockville, MD 20892, USA. ^[7] Galapagos, Leiden, the Netherlands. ^[8] Department of Pathology and Laboratory Medicine (Neurology), David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. ^[9] CHDI Foundation/CHDI Management Inc., Los Angeles, CA 90045, USA. ^[10] Center for Neurobehavioral Genetics, Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA. Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. UCLA Brain Research Institute, Los Angeles, CA 90095, USA. xwyang@mednet.ucla.edu. ^[11]