换一批Intraneuronal Aβ accumulation induces hippocampal neuron hyperexcitability through A-type K(+) current inhibition mediated by activation of caspases and GSK-3.
第一作者：
Federico,Scala
第一单位：
Institute of Human Physiology, Medical School, Università Cattolica, Rome, Italy.
作者：
医学主题词
动作电位(Action Potentials);阿尔茨海默病(Alzheimer Disease);淀粉样β肽类(Amyloid beta-Peptides);动物(Animals);半胱氨酸天冬氨酸蛋白酶(Caspases);细胞, 培养的(Cells, Cultured);疾病模型, 动物(Disease Models, Animal);电生理学现象(Electrophysiological Phenomena);糖原合成酶激酶3(Glycogen Synthase Kinase 3);海马(Hippocampus);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 转基因(Mice, Transgenic);分子靶向治疗(Molecular Targeted Therapy);神经元(Neurons);肽碎片(Peptide Fragments);磷酰化(Phosphorylation);Shal钾通道(Shal Potassium Channels)
DOI
10.1016/j.neurobiolaging.2014.10.034
PMID
25541422
发布时间
2023-11-11
- 浏览14
Neurobiology of aging
886-900页
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