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首页> Bioorganic & medicinal chemistry letters> An amidation/cyclization approach to the synthesis of N-hydroxyquinolinones and their biological evaluation as potential anti-plasmodial, anti-bacterial, and iron(II)-chelating agents.

An amidation/cyclization approach to the synthesis of N-hydroxyquinolinones and their biological evaluation as potential anti-plasmodial, anti-bacterial, and iron(II)-chelating agents.

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作者： Yanbo,Teng ^[1] ; Rossarin,Suwanarusk ^[2] ; Mun Hong,Ngai ^[1] ; Rajavel,Srinivasan ^[3] ; Alice Soh Meoy,Ong ^[2] ; Bow,Ho ^[4] ; Laurent,Rénia ^[2] ; Christina L L,Chai ^[5]

作者单位： Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore. ^[1] Singapore Immunology Network (SIgN), Agency for Science Technology and Research, (A(∗)STAR), 8A Biomedical Grove, Immunos Building, Singapore 138648, Singapore. ^[2] Institute of Chemical and Engineering Sciences (ICES), Agency for Science Technology and Research, (A(∗)STAR), 8 Biomedical Grove, Singapore 138665, Singapore. ^[3] Department of Microbiology, National University of Singapore, 5 Science Drive 2, Singapore 117545, Singapore. ^[4] Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore; Institute of Chemical and Engineering Sciences (ICES), Agency for Science Technology and Research, (A(∗)STAR), 8 Biomedical Grove, Singapore 138665, Singapore. ^[5]

关键词 Anti-bacterial activity Anti-plasmodial activity Iron chelation N-Hydroxyquinolinone

主题词酰胺类(Amides);抗菌药(Anti-Bacterial Agents);抗疟药(Antimalarials);催化作用(Catalysis);螯合剂(Chelating Agents);环化(Cyclization);大肠杆菌(Escherichia coli);亚铁化合物(Ferrous Compounds);钯(Palladium);疟原虫属(Plasmodium);喹诺酮类(Quinolones);金黄色葡萄球菌(Staphylococcus aureus);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.bmcl.2014.12.014

PMID 25544370

发布时间 2015-01-16

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Bioorganic & medicinal chemistry letters

Bioorganic & medicinal chemistry letters

2015年25卷3期

607-10页

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