Rb and FZR1/Cdh1 determine CDK4/6-cyclin D requirement in C. elegans and human cancer cells.

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作者： Inge,The ^[1] ; Suzan,Ruijtenberg ^[1] ; Benjamin P,Bouchet ^[2] ; Alba,Cristobal ^[3] ; Martine B W,Prinsen ^[1] ; Tim,van Mourik ^[1] ; John,Koreth ^[4] ; Huihong,Xu ^[5] ; Albert J R,Heck ^[3] ; Anna,Akhmanova ^[2] ; Edwin,Cuppen ^[6] ; Mike,Boxem ^[1] ; Javier,Muñoz ^[3] ; Sander,van den Heuvel ^[1]

作者单位： Developmental Biology, Faculty of Sciences, Department of Biology, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands. ^[1] Cell Biology, Faculty of Sciences, Department of Biology, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands. ^[2] Biomolecular Mass Spectrometry and Proteomics Group, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands. ^[3] Hematologic Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA. ^[4] Department of Pathology and Laboratory Medicine, Boston University School of Medicine and Boston Medical Center, 670 Albany Street, Boston, MA, USA. ^[5] Hubrecht Institute, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands. ^[6]

主题词动物(Animals);碱基序列(Base Sequence);秀丽新小杆线虫(Caenorhabditis elegans);漂亮新小杆线虫蛋白质类(Caenorhabditis elegans Proteins);细胞周期(Cell Cycle);细胞系, 肿瘤(Cell Line, Tumor);细胞周期蛋白D(Cyclin D);细胞周期蛋白依赖激酶4(Cyclin-Dependent Kinase 4);细胞周期蛋白依赖激酶6(Cyclin-Dependent Kinase 6);基因敲低技术(Gene Knockdown Techniques);HEK293细胞(HEK293 Cells);人类(Humans);免疫沉淀法(Immunoprecipitation);质谱分析法(Mass Spectrometry);显微镜检查, 荧光(Microscopy, Fluorescence);分子序列数据(Molecular Sequence Data);多蛋白复合物(Multiprotein Complexes);阻遏蛋白质类(Repressor Proteins);视网膜母细胞瘤蛋白质(Retinoblastoma Protein);序列分析, DNA(Sequence Analysis, DNA)

DOI 10.1038/ncomms6906

PMID 25562820

发布时间 2018-11-13

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Rb and FZR1/Cdh1 determine CDK4/6-cyclin D requirement in C. elegans and human cancer cells.

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Rb and FZR1/Cdh1 determine CDK4/6-cyclin D requirement in C. elegans and human cancer cells.

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