Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages.

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作者： Eva M,Palsson-McDermott ^[1] ; Anne M,Curtis ^[1] ; Gautam,Goel ^[2] ; Mario A R,Lauterbach ^[1] ; Frederick J,Sheedy ^[3] ; Laura E,Gleeson ^[3] ; Mirjam W M,van den Bosch ^[1] ; Susan R,Quinn ^[1] ; Raquel,Domingo-Fernandez ^[1] ; Daniel G W,Johnston ^[1] ; Jian-Kang,Jiang ^[4] ; William J,Israelsen ^[3] ; Joseph,Keane ^[5] ; Craig,Thomas ^[6] ; Clary,Clish ^[2] ; Matthew,Vander Heiden ^[7] ; Ramnik J,Xavier ; Luke A J,O'Neill

作者单位： School of Biochemistry and Immunology, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin 2, Ireland. ^[1] Centre for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Gastrointestinal Unit and Centre for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, MA 02142, USA. ^[2] Department of Clinical Medicine, School of Medicine, Trinity College, Dublin 2, Ireland. ^[3] Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. ^[4] National Institutes of Health (NIH), Chemical Genomics Centre, National Centre for Advancing Translational Sciences, NIH, Bethesda, MD 20892, USA. ^[5] Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, MA 02142, USA. ^[6] School of Biochemistry and Immunology, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin 2, Ireland. Electronic address: laoneill@tcd.ie. ^[7]