TAM receptor-dependent regulation of SOCS3 and MAPKs contributes to proinflammatory cytokine downregulation following chronic NOD2 stimulation of human macrophages.
第一作者:
Shasha,Zheng
第一单位:
Section of Digestive Diseases, Department of Internal Medicine, Yale University, New Haven, CT 06520.
作者:
主题词
动物(Animals);印迹法, 蛋白质(Blotting, Western);染色质免疫沉淀法(Chromatin Immunoprecipitation);结肠炎(Colitis);细胞因子类(Cytokines);减量调节(Down-Regulation);基因表达调控(Gene Expression Regulation);人类(Humans);炎症(Inflammation);巨噬细胞(Macrophages);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);丝裂原激活蛋白激酶类(Mitogen-Activated Protein Kinases);Nod2信号接头蛋白质(Nod2 Signaling Adaptor Protein);受体蛋白质酪氨酸激酶类(Receptor Protein-Tyrosine Kinases);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction);细胞因子信号转导蛋白抑制因子(Suppressor of Cytokine Signaling Proteins);转染(Transfection)
DOI
10.4049/jimmunol.1401933
PMID
25567680
发布时间
2018-11-13
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