A novel cofactor-binding mode in bacterial IMP dehydrogenases explains inhibitor selectivity.

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作者： Magdalena,Makowska-Grzyska ^[1] ; Youngchang,Kim ^[2] ; Natalia,Maltseva ^[1] ; Jerzy,Osipiuk ^[2] ; Minyi,Gu ^[1] ; Minjia,Zhang ^[3] ; Kavitha,Mandapati ^[3] ; Deviprasad R,Gollapalli ^[3] ; Suresh Kumar,Gorla ^[3] ; Lizbeth,Hedstrom ^[4] ; Andrzej,Joachimiak ^[5]

作者单位： From the Center for Structural Genomics of Infectious Diseases, Computational Institute, University of Chicago, Chicago, Illinois 60637. ^[1] From the Center for Structural Genomics of Infectious Diseases, the Structural Biology Center, Biosciences, Argonne National Laboratory, Argonne, Illinois 60439, and Computational Institute, University of Chicago, Chicago, Illinois 60637. ^[2] the Departments of Biology and. ^[3] the Departments of Biology and Chemistry, Brandeis University, Waltham, Massachusetts 024549110 hedstrom@brandeis.edu. ^[4] From the Center for Structural Genomics of Infectious Diseases, the Structural Biology Center, Biosciences, Argonne National Laboratory, Argonne, Illinois 60439, and Computational Institute, University of Chicago, Chicago, Illinois 60637, andrzejj@anl.gov. ^[5]

关键词 Antibacterial Antibiotic Resistance Cofactor-binding Site Cryptosporidium parvum-selective Inhibitors Enzyme Inhibitor Inosine 5′-Monophosphate Dehydrogenase Ligand-binding Protein Microbial Pathogenesis Nicotinamide Adenine Dinucleotide (NAD)