Design and synthesis of new dihydrotestosterone derivative with positive inotropic activity.

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作者： Figueroa-Valverde,Lauro ^[1] ; Díaz-Cedillo,Francisco ^[2] ; García-Cervera,Elodia ^[3] ; Pool-Gómez,Eduardo ^[3] ; Rosas-Nexticapa,Marcela ^[4] ; Hau-Heredia,Lenin ^[3] ; Sarabia Alcocer,Betty ^[5]

作者单位： Laboratory of Pharmaco-Chemistry, Faculty of Chemical Biological Sciences, University Autonomous of Campeche, Av. Agustín Melgar s/n, Col Buenavista C.P. 24039 Campeche Cam., Mexico. Electronic address: lauro_1999@yahoo.com. ^[1] Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional. Prol. Carpio y Plan de Ayala s/n Col. Santo Tomas, D.F. C.P. 11340, Mexico. ^[2] Laboratory of Pharmaco-Chemistry, Faculty of Chemical Biological Sciences, University Autonomous of Campeche, Av. Agustín Melgar s/n, Col Buenavista C.P. 24039 Campeche Cam., Mexico. ^[3] Facultad de Nutrición, Universidad Veracruzana, Médicos y Odontologos s/n C.P. 91010, Unidad del Bosque Xalapa Veracruz, Mexico. ^[4] Faculty of Medicine, University Autonomous of Campeche, Av. Patricio Trueba de Regil s/n, Col Lindavista C.P. 24090 Campeche Cam., Mexico. ^[5]

关键词 Dihydrotestosterone derivative Inotropic activity Metoprolol Synthesis

主题词动物(Animals);强心药(Cardiotonic Agents);双氢睾酮(Dihydrotestosterone);药物设计(Drug Design);心室(Heart Ventricles);大鼠(Rats);心室功能, 左(Ventricular Function, Left)

DOI 10.1016/j.steroids.2014.12.026

PMID 25578737

发布时间 2015-02-09

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