Association of TERT promoter mutation 1,295,228 C>T with BRAF V600E mutation, older patient age, and distant metastasis in anaplastic thyroid cancer.
第一作者:
Xiaoguang,Shi
第一单位:
Laboratory for Cellular and Molecular Thyroid Research (X.S., R.L., G.Z., X.L., M.X.), Division of Endocrinology, Diabetes & Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287; Department of Endocrinology & Metabolism (S.Q.), Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China; Department of Pathology (J.B.), The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287; Jilin Provincial Key Laboratory of Surgical Translational Medicine (H.S.), Department of Thyroid and Parathyroid Surgery, China-Japan Union Hospital, Jilin University, Changchun, Jilin Province 130033, China; Department of Pathology (E.W.), The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province 110001, China; Department of Medical Image (Y.L.), Liaoning Cancer Hospital & Institute, Shenyang, Liaoning Province 110001, China; Department of Pathology (X.Y.), Shengjing Hospital of China Medical University, Shenyang, Liaoning Province 110004, China; Department of Endocrinology (J.Z.), Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province 250021, China; Department of Endocrinology (J.D.), The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province 116011, China; Department of Pathology (A.K.E.-N.), University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030; and The Endocrine Institute and The Liaoning Provincial Key Laboratory of Endocrine Diseases (X.S., Z.S., W.T.), Department of Endocrinology and Metabolism, The First Hospital of China Medical University, Shenyang, Liaoning Province 110001, China.
作者:
主题词
年龄因素(Age Factors);老年人(Aged);老年人, 80以上(Aged, 80 and over);氨基酸取代(Amino Acid Substitution);上位性, 遗传(Epistasis, Genetic);女(雌)性(Female);遗传关联研究(Genetic Association Studies);谷氨酸(Glutamic Acid);人类(Humans);男(雄)性(Male);中年人(Middle Aged);多态性, 单核苷酸(Polymorphism, Single Nucleotide);启动区, 遗传(Promoter Regions, Genetic);原癌基因蛋白质B-raf(Proto-Oncogene Proteins B-raf);末端转移酶端粒(Telomerase);甲状腺肿瘤(Thyroid Neoplasms);缬氨酸(Valine)
DOI
10.1210/jc.2014-3606
PMID
25584719
发布时间
2018-11-13
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