换一批Activation of autophagy via Ca(2+)-dependent AMPK/mTOR pathway in rat notochordal cells is a cellular adaptation under hyperosmotic stress.
第一作者：
Li-Bo,Jiang
第一单位：
a Department of Orthopedic Surgery; Zhongshan Hospital ; Fudan University ; Shanghai , China.
作者：
关键词
AMPK, AMP activated Protein KinaseAdaptationApoptosisAutophagyBAPTA-AM, bis-(o-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid, tetra(acetoxymethyl) esterDAPI, 4′, 6-diamidino-2-phenylindoleECM, extracellular matrixEGTA, ethyleneglycol-bis (2-aminoethylether)-N,N,N′, N-tetraacetic acidFITC, fluorescein isothiocyanateHyperosmotic stressIDD, Intervertebral disc degenerationJC-1, 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolyl-carbocyanine iodideMAPK, mitogen-activated protein kinaseMDC, MonodansylcadaverineMMP, mitochondrial membrane potentialMPT, mitochondrial permeability transitionNP, nucleus pulposusNotochordal cellsOD, optical densityPI, propidium iodidePLC, phospholipase CSQSTM1, Sequestosome-1TRPV4, Transient receptor potential vanilloid 4fluo3-AM, fluo3 acetoximethylestermTOR, mammalian target of rapamycin
医学主题词
AMP活化蛋白激酶类(AMP-Activated Protein Kinases);适应, 生理学(Adaptation, Physiological);动物(Animals);细胞凋亡(Apoptosis);自噬(Autophagy);印迹法, 蛋白质(Blotting, Western);钙(Calcium);荧光抗体技术(Fluorescent Antibody Technique);基因沉默(Gene Silencing);热休克蛋白质类(Heat-Shock Proteins);细胞内间隙(Intracellular Space);模型, 生物学(Models, Biological);脊索(Notochord);渗透压(Osmotic Pressure);吞噬体(Phagosomes);蛋白质类(Proteins);RNA, 小分子干扰(RNA, Small Interfering);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);信号传导(Signal Transduction);染色与标记(Staining and Labeling);应激, 生理学(Stress, Physiological);TOR丝氨酸-苏氨酸激酶(TOR Serine-Threonine Kinases)
DOI
10.1080/15384101.2015.1004946
PMID
25590373
发布时间
2022-04-08
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