Alterations in the interactome of serine/threonine protein phosphatase type-1 in atrial fibrillation patients.

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作者： David Y,Chiang ^[1] ; Nicolas,Lebesgue ^[2] ; David L,Beavers ^[1] ; Katherina M,Alsina ^[3] ; J Mirjam A,Damen ^[2] ; Niels,Voigt ^[4] ; Dobromir,Dobrev ^[4] ; Xander H T,Wehrens ^[5] ; Arjen,Scholten ^[6]

作者单位： Cardiovascular Research Institute, Baylor College of Medicine, Houston, Texas; Department of Molecular Physiology & Biophysics, Baylor College of Medicine, Houston, Texas; Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, Texas. ^[1] Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands; Netherlands Proteomics Centre, the Netherlands. ^[2] Cardiovascular Research Institute, Baylor College of Medicine, Houston, Texas; Department of Molecular Physiology & Biophysics, Baylor College of Medicine, Houston, Texas. ^[3] Institute of Pharmacology, Faculty of Medicine, University Duisburg-Essen, Essen, Germany. ^[4] Cardiovascular Research Institute, Baylor College of Medicine, Houston, Texas; Department of Molecular Physiology & Biophysics, Baylor College of Medicine, Houston, Texas; Department of Medicine (Cardiology), Baylor College of Medicine, Houston, Texas. Electronic address: wehrens@bcm.edu. ^[5] Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands; Netherlands Proteomics Centre, the Netherlands; Janssen Infectious Diseases and Vaccines, Crucell Holland B.V., Leiden, the Netherlands. Electronic address: a.scholten@uu.nl. ^[6]

关键词 PP1 regulatory subunits atrial fibrillation label-free quantification mass spectrometry protein phosphatase 1 proteomics