Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 1: C2-symmetric inhibitors with diyne and biphenyl linkers.

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作者： Simon,Giroux ^[1] ; Darius,Bilimoria ^[2] ; Caroline,Cadilhac ^[2] ; Kevin M,Cottrell ^[1] ; Francois,Denis ^[2] ; Evelyne,Dietrich ^[2] ; Nigel,Ewing ^[1] ; James A,Henderson ^[1] ; Lucille,L'Heureux ^[2] ; Nagraj,Mani ^[1] ; Mark,Morris ^[1] ; Olivier,Nicolas ^[2] ; T Jagadeeswar,Reddy ^[2] ; Subajini,Selliah ^[2] ; Rebecca S,Shawgo ^[1] ; Jinwang,Xu ^[1] ; Nathalie,Chauret ^[2] ; Francoise,Berlioz-Seux ^[1] ; Laval C,Chan ^[2] ; Sanjoy K,Das ^[2] ; Anne-Laure,Grillot ^[1] ; Youssef L,Bennani ^[1] ; John P,Maxwell ^[1]

作者单位： Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, USA. ^[1] Vertex Pharmaceuticals Canada Inc., 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada. ^[2]

关键词 HCV Hepatitis C NS5a Thienoimidazole

主题词抗病毒药(Antiviral Agents);药物发现(Drug Discovery);咪唑类(Imidazoles);病毒非结构蛋白质类(Viral Nonstructural Proteins)

DOI 10.1016/j.bmcl.2014.12.046

PMID 25595681

发布时间 2022-01-10

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