MiR-21 alleviates secondary blood-brain barrier damage after traumatic brain injury in rats.

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作者： Xintong,Ge ^[1] ; Zhaoli,Han ^[2] ; Fanglian,Chen ^[3] ; Haichen,Wang ^[4] ; Baoliang,Zhang ^[1] ; Rongcai,Jiang ^[1] ; Ping,Lei ^[5] ; Jianning,Zhang ^[6]

作者单位： Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education, Tianjin 300052, China; Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin 300052, China; Laboratory of Neuro-Trauma, Tianjin Neurological Institute, Tianjin 300052, China; Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China. ^[1] Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education, Tianjin 300052, China; Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin 300052, China; Laboratory of Neuro-Trauma, Tianjin Neurological Institute, Tianjin 300052, China; Department of Geriatrics, Tianjin Medical University General Hospital, Tianjin 300052, China; Laboratory of Neuro-Trauma and Neurodegenerative Disorders, Tianjin Geriatrics Institute, Tianjin 300052, China. ^[2] Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education, Tianjin 300052, China; Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin 300052, China; Laboratory of Neuro-Trauma, Tianjin Neurological Institute, Tianjin 300052, China. ^[3] Department of Neurology, Duke University School of Medicine, Durham, NC 27710, USA. ^[4] Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China; Department of Geriatrics, Tianjin Medical University General Hospital, Tianjin 300052, China; Laboratory of Neuro-Trauma and Neurodegenerative Disorders, Tianjin Geriatrics Institute, Tianjin 300052, China. Electronic address: leiping1974@163.com. ^[5] Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education, Tianjin 300052, China; Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin 300052, China; Laboratory of Neuro-Trauma, Tianjin Neurological Institute, Tianjin 300052, China; Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China. Electronic address: jianningzhang@hotmail.com. ^[6]

关键词 Blood–brain barrier Gene therapy Secondary brain damage Traumatic brain injury miR-21