Optimisation of in silico derived 2-aminobenzimidazole hits as unprecedented selective kappa opioid receptor agonists.

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作者： Pradip K,Sasmal ^[1] ; C Vamsee,Krishna ^[2] ; S Sudheerkumar,Adabala ^[2] ; M,Roshaiah ^[2] ; Khaji Abdul,Rawoof ^[2] ; Emima,Thadi ^[2] ; K Pavan,Sukumar ^[2] ; Srisailam,Cheera ^[2] ; Chandrasekhar,Abbineni ^[2] ; K V L Narasimha,Rao ^[2] ; A,Prasanthi ^[2] ; Kamal,Nijhawan ^[2] ; Mahaboobi,Jaleel ^[2] ; Lakshmi Ramachandran,Iyer ^[2] ; T Krishna,Chaitanya ^[2] ; Nirbhay Kumar,Tiwari ^[2] ; N Lavanya,Krishna ^[2] ; Vijay,Potluri ^[2] ; Ish,Khanna ^[2] ; Thomas M,Frimurer ^[3] ; Michael,Lückmann ^[4] ; Øystein,Rist ^[5] ; Lisbeth,Elster ^[5] ; Thomas,Högberg ^[6]

作者单位： Discovery Research, Dr. Reddy's Laboratories Ltd, Bollaram Road, Miyapur, Hyderabad 500049, India. Electronic address: pradipks@drreddys.com. ^[1] Discovery Research, Dr. Reddy's Laboratories Ltd, Bollaram Road, Miyapur, Hyderabad 500049, India. ^[2] 7TM Pharma A/S, Fremtidsvej 3, DK-2970 Hørsholm, Denmark; NNF, Center for Protein Research and NNF Center for Basic Metabolic Research, University of Copenhagen, Denmark. ^[3] NNF, Center for Protein Research and NNF Center for Basic Metabolic Research, University of Copenhagen, Denmark. ^[4] 7TM Pharma A/S, Fremtidsvej 3, DK-2970 Hørsholm, Denmark. ^[5] 7TM Pharma A/S, Fremtidsvej 3, DK-2970 Hørsholm, Denmark. Electronic address: thomas.hogberg@leo-pharma.com. ^[6]

关键词 Anti-nociception Benzimidazoles KOR agonists Kappa opioid receptor (KOR)