首页> Journal of medicinal chemistry> Synthesis and pharmacological characterization of C4-disubstituted analogs of 1S,2S,5R,6S-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: identification of a potent, selective metabotropic glutamate receptor agonist and determination of agonist-bound human mGlu2 and mGlu3 amino terminal domain structures.

Synthesis and pharmacological characterization of C4-disubstituted analogs of 1S,2S,5R,6S-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: identification of a potent, selective metabotropic glutamate receptor agonist and determination of agonist-bound human mGlu2 and mGlu3 amino terminal domain structures.

导出 LinkOut

翻译打印收藏纠错

第一作者： James A,Monn

第一单位： Discovery Chemistry Research and Technologies, ‡Quantitative Biology, §Structural Biology, ∥Drug Disposition, and ⊥Neuroscience Research, Eli Lilly and Company , Indianapolis, Indiana 46285, United States.

作者： James A,Monn ^[1] ; Lourdes,Prieto ; Lorena,Taboada ; Concepcion,Pedregal ; Junliang,Hao ; Matt R,Reinhard ; Steven S,Henry ; Paul J,Goldsmith ; Christopher D,Beadle ; Lesley,Walton ; Teresa,Man ; Helene,Rudyk ; Barry,Clark ; David,Tupper ; S Richard,Baker ; Carlos,Lamas ; Carlos,Montero ; Alicia,Marcos ; Jaime,Blanco ; Mark,Bures ; David K,Clawson ; Shane,Atwell ; Frances,Lu ; Jing,Wang ; Marijane,Russell ; Beverly A,Heinz ; Xushan,Wang ; Joan H,Carter ; Chuanxi,Xiang ; John T,Catlow ; Steven,Swanson ; Helen,Sanger ; Lisa M,Broad ; Michael P,Johnson ; Kelly L,Knopp ; Rosa M A,Simmons ; Bryan G,Johnson ; David B,Shaw ; David L,McKinzie

作者单位： Discovery Chemistry Research and Technologies, ‡Quantitative Biology, §Structural Biology, ∥Drug Disposition, and ⊥Neuroscience Research, Eli Lilly and Company , Indianapolis, Indiana 46285, United States. ^[1]