Arginine methylation and citrullination of splicing factor proline- and glutamine-rich (SFPQ/PSF) regulates its association with mRNA.

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第一作者： Ambrosius P,Snijders

第一单位： ChELSI Institute, Chemical and Biological Engineering, University of Sheffield, Sheffield S1 3JD, United Kingdom.

作者： Ambrosius P,Snijders ^[1] ; Guillaume M,Hautbergue ^[2] ; Alex,Bloom ^[3] ; James C,Williamson ^[1] ; Thomas C,Minshull ^[1] ; Helen L,Phillips ^[1] ; Simeon R,Mihaylov ^[2] ; Douglas T,Gjerde ^[4] ; David P,Hornby ^[3] ; Stuart A,Wilson ^[3] ; Paul J,Hurd ^[5] ; Mark J,Dickman ^[6]

作者单位： ChELSI Institute, Chemical and Biological Engineering, University of Sheffield, Sheffield S1 3JD, United Kingdom. ^[1] Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield S10 2HQ, United Kingdom. ^[2] Department of Molecular Biology and Biotechnology, Krebs Institute, University of Sheffield, Sheffield S10 2TN, United Kingdom. ^[3] PhyNexus Inc., San Jose, California 95136, USA. ^[4] School of Biological and Chemical Sciences, Queen Mary University of London, London E1 4NS, United Kingdom. ^[5] ChELSI Institute, Chemical and Biological Engineering, University of Sheffield, Sheffield S1 3JD, United Kingdom m.dickman@sheffield.ac.uk. ^[6]

关键词 arginine methylation citrullination mRNP binding mass spectrometry non-POU domain-containing octamer-binding protein polypyrimidine tract-binding protein-associated-splicing factor splicing factor proline- and glutamine-rich