换一批
第一作者：
Li,Peng
第一单位：
a Department of Antibody Discovery and Protein Engineering ; MedImmune LLC ; Gaithersburg , MD USA.
作者：
关键词
APBS, Adaptive Poisson-Boltzmann SolverBSA, bovine serum albuminCDR, complementarity-determining regionCHARMm, Chemistry at HARvard Macromolecular MechanicsCHO, Chinese hamster ovaryEDTA, ethylene diamine tetra-acetic acidELISA, enzyme-linked immunosorbant assayFBS, fetal bovine serumFab, fragment antigen-bindingFc, fragment crystallizableIFN, interferonIFNAR1IFNAR1, interferon alpha receptor 1IFNAR2, interferon alpha receptor 2IgG, immunoglobulinKD, equilibrium dissociation constantL-Cys, L-cysteineMEDI546MEMα, minimum essential alphaMLE, murine lung epithelialPBS, phosphate buffered salinePBST, phosphate buffered saline tabletsPCR, polymerase chain reactionPDB, protein data bankPVDF, polyvinylidene difluoridePh.D., phage displayPyMOL, python-enhanced molecular graphics toolRDOCK, rigid-body docking algorithmRU, resonance unitsSDS–PAGE, sodium dodecyl sulfate polyacrylamide gel electrophoresisSPR, surface plasmon resonanceVH, variable heavyVL, variable lightZDOCK, rigid-body docking algorithmanifrolumabenzymatic fragmentationepitope mappingkDa, kilodaltonsmutagenesisphage-peptide displayprotein dockingsystemic sclerosis?, ?ngstr?m
医学主题词
氨基酸取代(Amino Acid Substitution);动物(Animals);抗体, 单克隆(Antibodies, Monoclonal);自身免疫疾病(Autoimmune Diseases);CHO细胞(CHO Cells);仓鼠亚科(Cricetinae);仓鼠属(Cricetulus);表位作图(Epitope Mapping);表位(Epitopes);干扰素类(Interferons);男(雄)性(Male);突变, 误义(Mutation, Missense);肽库(Peptide Library);受体, 干扰素αβ(Receptor, Interferon alpha-beta)
DOI
10.1080/19420862.2015.1007810
PMID
25606664
发布时间
2022-03-30
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