Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci.-论文-万方医学网

第一作者： Regina C,Betz

第一单位： Institute of Human Genetics, University of Bonn, Bonn, Germany.

作者： Regina C,Betz ^[1] ; Lynn,Petukhova ^[2] ; Stephan,Ripke ^[3] ; Hailiang,Huang ^[4] ; Androniki,Menelaou ^[5] ; Silke,Redler ^[4] ; Tim,Becker ^[5] ; Stefanie,Heilmann ^[6] ; Tarek,Yamany ^[1] ; Madeliene,Duvic ^[7] ; Maria,Hordinsky ^[8] ; David,Norris ^[1] ; Vera H,Price ^[9] ; Julian,Mackay-Wiggan ^[2] ; Annemieke,de Jong ^[10] ; Gina M,DeStefano ^[11] ; Susanne,Moebus ^[12] ; Markus,Böhm ^[13] ; Ulrike,Blume-Peytavi ^[2] ; Hans,Wolff ^[2] ; Gerhard,Lutz ^[14] ; Roland,Kruse ^[15] ; Li,Bian ^[16] ; Christopher I,Amos ^[17] ; Annette,Lee ^[18] ; Peter K,Gregersen ^[19] ; Bettina,Blaumeiser ^[20] ; David,Altshuler ^[2] ; Raphael,Clynes ^[21] ; Paul I W,de Bakker ^[22] ; Markus M,Nöthen ^[22] ; Mark J,Daly ^[23] ; Angela M,Christiano ^[4]

作者单位： Institute of Human Genetics, University of Bonn, Bonn, Germany. ^[1] Department of Dermatology, Columbia University, NY, NY. ^[2] Department of Epidemiology, Columbia University, NY, NY. ^[3] Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA. ^[4] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA. ^[5] Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands. ^[6] German Center for Neurodegenerative Diseases, Bonn, Germany. ^[7] Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn. ^[8] Department of Genomics, Life&Brain Center, University Bonn, Bonn, Germany. ^[9] Department of Dermatology, MD Anderson Cancer Center, Houston,TX. ^[10] Department of Dermatology, University of Minnesota, Minneapolis, MN. ^[11] Department of Dermatology, University of Colorado, Denver, CO, US. ^[12] Department of Dermatology, University of California, San Francisco, San Francisco CA. ^[13] Department of Genetics & Development, Columbia University, NY, NY. ^[14] Institute of Medical Informatics, Biometry, and Epidemiology, University Duisburg-Essen, Essen, Germany. ^[15] Department of Dermatology, University of Münster, Münster, Germany. ^[16] Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany. ^[17] Department of Dermatology, University of Munich, Munich, Germany. ^[18] Dermatological Practice, Hair and Nail, Wesseling, Germany. ^[19] Dermatological Practice, Paderborn, Germany. ^[20] Community and Family Medicine and Genetics, Dartmouth College, Hanover, NH, US. ^[21] The Feinstein Institute for Medical Research, Manhasset NY. ^[22] Department of Medical Genetics, University of Antwerp, Antwerp, Belgium. ^[23] Department of Medicine Columbia University, NY, NY. ^[24] Department of Epidemiology, University Medical Center Utrecht, Utrecht, The Netherlands. ^[25]

主题词衔接蛋白质类, 信号转导(Adaptor Proteins, Signal Transducing);等位基因(Alleles);斑秃(Alopecia Areata);动物(Animals);凋亡调节蛋白质类(Apoptosis Regulatory Proteins);病例对照研究(Case-Control Studies);女(雌)性(Female);疾病遗传易感性(Genetic Predisposition to Disease);全基因组关联研究(Genome-Wide Association Study);HLA抗原(HLA Antigens);人类(Humans);细胞内信号肽和蛋白质类(Intracellular Signaling Peptides and Proteins);男(雄)性(Male);膜蛋白质类(Membrane Proteins);小鼠(Mice);显微镜检查, 荧光(Microscopy, Fluorescence);寡核苷酸序列分析(Oligonucleotide Array Sequence Analysis);表型(Phenotype);多态性, 单核苷酸(Polymorphism, Single Nucleotide);主成分分析(Principal Component Analysis);蛋白质构象(Protein Conformation);蛋白质类(Proteins);原癌基因蛋白质类(Proto-Oncogene Proteins);皮肤(Skin)

DOI 10.1038/ncomms6966

PMID 25608926

发布时间 2022-03-31

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Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci.

Nature communications

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Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci.

Nature communications

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Nature communications

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