Histone H3K9 demethylase JMJD1A modulates hepatic stellate cells activation and liver fibrosis by epigenetically regulating peroxisome proliferator-activated receptor γ.
第一作者:
Yan,Jiang
第一单位:
*State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences; Institutes of Biomedical Sciences of Shanghai Medical College, Fudan University, Shanghai, China; Department of Chemistry, Fudan University, Shanghai, China; and State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China.
作者:
主题词
动物(Animals);印迹法, 蛋白质(Blotting, Western);细胞, 培养的(Cells, Cultured);染色质免疫沉淀法(Chromatin Immunoprecipitation);表观基因组学(Epigenomics);流式细胞术(Flow Cytometry);基因表达调控(Gene Expression Regulation);肝星状细胞(Hepatic Stellate Cells);组蛋白类(Histones);人类(Humans);含Jumonji结构域组蛋白脱甲基酶类(Jumonji Domain-Containing Histone Demethylases);肝硬化(Liver Cirrhosis);男(雄)性(Male);小鼠(Mice);PPARγ(PPAR gamma);RNA, 信使(RNA, Messenger);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction)
DOI
10.1096/fj.14-251751
PMID
25609425
发布时间
2022-03-21
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FASEB journal
1830-41页
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