Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation.

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第一作者： Julia R,Clarke

第一单位： Institute of Medical Biochemistry Leopoldo de Meis Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil School of Pharmacy Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

作者： Julia R,Clarke ^[1] ; Natalia M,Lyra E Silva ^[2] ; Claudia P,Figueiredo ^[3] ; Rudimar L,Frozza ^[2] ; Jose H,Ledo ^[2] ; Danielle,Beckman ^[2] ; Carlos K,Katashima ^[4] ; Daniela,Razolli ^[4] ; Bruno M,Carvalho ^[4] ; Renata,Frazão ^[5] ; Marina A,Silveira ^[5] ; Felipe C,Ribeiro ^[2] ; Theresa R,Bomfim ^[2] ; Fernanda S,Neves ^[3] ; William L,Klein ^[6] ; Rodrigo,Medeiros ^[7] ; Frank M,LaFerla ^[7] ; Jose B,Carvalheira ^[4] ; Mario J,Saad ^[4] ; Douglas P,Munoz ^[8] ; Licio A,Velloso ^[4] ; Sergio T,Ferreira ^[9] ; Fernanda G,De Felice ^[10]

作者单位： Institute of Medical Biochemistry Leopoldo de Meis Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil School of Pharmacy Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. ^[1] Institute of Medical Biochemistry Leopoldo de Meis Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. ^[2] School of Pharmacy Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. ^[3] Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas, Campinas, SP, Brazil. ^[4] Department of Anatomy, Institute of Biomedical Sciences University of São Paulo, SP, Brazil. ^[5] Department of Neurobiology, Northwestern University, Evanston, IL, USA. ^[6] Institute for Memory Impairments and Neurological Disorders University of California, Irvine, CA, USA. ^[7] Center for Neuroscience Studies, Queen's University, Kingston, ON, Canada. ^[8] Institute of Medical Biochemistry Leopoldo de Meis Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil Institute of Biophysics Carlos Chagas Filho Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. ^[9] Institute of Medical Biochemistry Leopoldo de Meis Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil felice@bioqmed.ufrj.br. ^[10]

关键词 Alzheimer's disease ER stress hypothalamus inflammation insulin resistance