Symptomatic improvement, increased life-span and sustained cell homing in amyotrophic lateral sclerosis after transplantation of human umbilical cord blood cells genetically modified with adeno-viral vectors expressing a neuro-protective factor and a neural cell adhesion molecule.
作者:
主题词
肌萎缩侧索硬化(Amyotrophic Lateral Sclerosis);动物(Animals);细胞移植(Cell Transplantation);依赖病毒(Dependovirus);女(雌)性(Female);胎血(Fetal Blood);遗传载体(Genetic Vectors);胶质细胞源性神经营养因子(Glial Cell Line-Derived Neurotrophic Factor);HEK293细胞(HEK293 Cells);人类(Humans);预期寿命(Life Expectancy);男(雄)性(Male);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);神经细胞黏附分子类(Neural Cell Adhesion Molecules);血管内皮生长因子A(Vascular Endothelial Growth Factor A)
DOI
10.2174/1566523215666150126122317
PMID
25619885
发布时间
2019-11-13
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Current gene therapy
266-76页
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