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Solid microparticles based on chitosan or methyl-β-cyclodextrin: a first formulative approach to increase the nose-to-brain transport of deferoxamine mesylate.

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第一作者： Giovanna,Rassu

第一单位： Department of Chemistry and Pharmacy, University of Sassari, via Muroni 23/a, 07100 Sassari, Italy.

作者： Giovanna,Rassu ^[1] ; Elena,Soddu ^[1] ; Massimo,Cossu ^[1] ; Antonio,Brundu ^[2] ; Guido,Cerri ^[2] ; Nicola,Marchetti ^[3] ; Luca,Ferraro ^[4] ; Raymond F,Regan ^[5] ; Paolo,Giunchedi ^[1] ; Elisabetta,Gavini ^[6] ; Alessandro,Dalpiaz ^[3]

作者单位： Department of Chemistry and Pharmacy, University of Sassari, via Muroni 23/a, 07100 Sassari, Italy. ^[1] Department of Natural and Territorial Sciences, University of Sassari, via Piandanna 4, 07100 Sassari, Italy. ^[2] Department of Chemical and Pharmaceutical Sciences, University of Ferrara, via Fossato di Mortara 19, 44121 Ferrara, Italy. ^[3] Department of Life Sciences and Biotechnology, University of Ferrara, via Borsari 46, 44121 Ferrara, Italy. ^[4] Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, USA. ^[5] Department of Chemistry and Pharmacy, University of Sassari, via Muroni 23/a, 07100 Sassari, Italy. Electronic address: eligav@uniss.it. ^[6]

关键词 Chitosan chloride Deferoxamine mesylate Methyl-β-cyclodextrin Nasal formulations Nose-to-brain transport Pharmacokinetic studies