Emergence of Multiple EGFR Extracellular Mutations during Cetuximab Treatment in Colorectal Cancer.

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作者： Sabrina,Arena ^[1] ; Beatriz,Bellosillo ^[2] ; Giulia,Siravegna ^[3] ; Alejandro,Martínez ^[4] ; Israel,Cañadas ^[5] ; Luca,Lazzari ^[3] ; Noelia,Ferruz ^[6] ; Mariangela,Russo ^[3] ; Sandra,Misale ^[7] ; Iria,González ^[8] ; Mar,Iglesias ^[9] ; Elena,Gavilan ^[5] ; Giorgio,Corti ^[7] ; Sebastijan,Hobor ^[7] ; Giovanni,Crisafulli ^[7] ; Marta,Salido ^[9] ; Juan,Sánchez ^[10] ; Alba,Dalmases ^[2] ; Joaquim,Bellmunt ^[5] ; Gianni,De Fabritiis ^[11] ; Ana,Rovira ^[5] ; Federica,Di Nicolantonio ^[3] ; Joan,Albanell ^[12] ; Alberto,Bardelli ^[13] ; Clara,Montagut ^[14]

作者单位： Candiolo Cancer Institute-FPO, IRCCS, Candiolo, Italy. Department of Oncology, University of Torino, Candiolo, Italy. FIRC Institute of Molecular Oncology (IFOM), Milano, Italy. ^[1] Cancer Research Program, IMIM (Institut Hospital del Mar Investigacions Mediques), Hospital del Mar, Barcelona, Spain. Department of Pathology, Hospital del Mar, Barcelona, Spain. ^[2] Candiolo Cancer Institute-FPO, IRCCS, Candiolo, Italy. Department of Oncology, University of Torino, Candiolo, Italy. ^[3] Cancer Research Program, IMIM (Institut Hospital del Mar Investigacions Mediques), Hospital del Mar, Barcelona, Spain. Department of Medical Oncology, Hospital del Mar, Barcelona, Spain. ^[4] Cancer Research Program, IMIM (Institut Hospital del Mar Investigacions Mediques), Hospital del Mar, Barcelona, Spain. ^[5] Computational Biophysics Laboratory (GRIB-IMIM), Pompeu Fabra University, PRBB, Barcelona, Spain. ^[6] Candiolo Cancer Institute-FPO, IRCCS, Candiolo, Italy. ^[7] Department of Medical Oncology, Hospital del Mar, Barcelona, Spain. ^[8] Department of Pathology, Hospital del Mar, Barcelona, Spain. ^[9] Department of Radiology, Hospital del Mar, Barcelona, Spain. ^[10] Computational Biophysics Laboratory (GRIB-IMIM), Pompeu Fabra University, PRBB, Barcelona, Spain. Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain. ^[11] Cancer Research Program, IMIM (Institut Hospital del Mar Investigacions Mediques), Hospital del Mar, Barcelona, Spain. Department of Medical Oncology, Hospital del Mar, Barcelona, Spain. Pompeu Fabra University, Barcelona, Spain. ^[12] Candiolo Cancer Institute-FPO, IRCCS, Candiolo, Italy. Department of Oncology, University of Torino, Candiolo, Italy. cmontagut@hospitaldelmar.cat alberto.bardelli@unito.it. ^[13] Cancer Research Program, IMIM (Institut Hospital del Mar Investigacions Mediques), Hospital del Mar, Barcelona, Spain. Department of Medical Oncology, Hospital del Mar, Barcelona, Spain. cmontagut@hospitaldelmar.cat alberto.bardelli@unito.it. ^[14]