换一批Overexpression of HOX genes is prevalent in Ewing sarcoma and is associated with altered epigenetic regulation of developmental transcription programs.
第一作者：
Laurie K,Svoboda
第一单位：
a Translational Oncology Program and the Departments of Pediatric and Communicable Diseases; University of Michigan ; Ann Arbor , MI USA.
作者：
关键词
ARMS, alveolar rhabdomyosarcomaBM-MSC, adult bone marrow-derived mesenchymal stem cellsChIP, chromatin immunoprecipitationChIP-seq, chromatin immunoprecipitation/high throughput sequencingERMS, embryonal rhabdomyosarcomaES, Ewing sarcomaEwing sarcomaGCR, global control regionHOXHOX, homeoboxMSC, mesenchymal stem cellsNC-MSC, neural crest stem cell-derived mesenchymal stem cellsNCSC, neural crest stem cellsOS, osteosarcomaPCA, principal components analysisPRE, polycomb response elementRT-PCR, reverse transcriptase polymerase chain reactionepigenetichESC, human embryonic stem cellspolycombqPCR, quantitative polymerase chain reaction
医学主题词
骨肿瘤(Bone Neoplasms);细胞分化(Cell Differentiation);细胞系, 肿瘤(Cell Line, Tumor);后成说, 遗传(Epigenesis, Genetic);基因表达调控, 发育期(Gene Expression Regulation, Developmental);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);基因沉默(Gene Silencing);基因, 同源盒(Genes, Homeobox);同源盒结构域蛋白质类(Homeodomain Proteins);人类(Humans);多基因族(Multigene Family);癌基因蛋白质类, 融合(Oncogene Proteins, Fusion);原癌基因蛋白质c-fli-1(Proto-Oncogene Protein c-fli-1);RNA结合蛋白质EWS(RNA-Binding Protein EWS);干细胞(Stem Cells);转录因子(Transcription Factors);转录, 遗传(Transcription, Genetic)
DOI
10.4161/15592294.2014.988048
PMID
25625846
发布时间
2018-11-13
- 浏览59
Epigenetics
1613-25页
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