换一批OASIS/CREB3L1 is epigenetically silenced in human bladder cancer facilitating tumor cell spreading and migration in vitro.
第一作者：
Michael,Rose
第一单位：
a Molecular Oncology Group; Institute of Pathology ; RWTH Aachen University ; Aachen , Germany.
作者：
关键词
ATCC, American Type Culture CollectionBMP-2, bone morphogenetic protein 2CA, CaliforniaCIS, Carcinoma in situCREB3L1, element binding protein 3-like 1DAB, 3-3′ diaminobenzidineDAC, 5-aza-2′-deoxycytidineDNA, desoxyribonucleic acidEK, ethics committeeER, endoplasmic reticulumFC, fold changeFFPE, formalin fixed paraffin embeddedG1, well differentiatedG2, moderately differentiatedG3, poorly differentiatedGAPDH, glyceraldehyde 3-phosphate dehydrogenaseHCV, Hepatitis C virusHPV, human papilloma virusHTRA (1-4), high-temperature requirement factor A (1-4)HTRA3IQR, interquartile rangeIRS, immunoreactive scoreLMU, Ludwig-Maximilians-UniversityM, methylatedMIBC, muscle invasive bladder cancerMSP, methylation specific PCRNMIBC, non-muscle invasive bladder cancerNU, normal urotheliumOASIS / CREB3L1OASIS, old astrocyte specifically-induced substancePCR, polymerase chain reactionRIP, regulated intramembrane proteolysisRWTH, Rheinisch Westf?lisch Technische HochschuleSP1, site 1 proteaseSP2, site 2 proteaseTCGA, The Cancer Genome AtlasTGF-β, transforming growth factor betaTSA, trichostatin ATSS, transcription start siteU, unmethylatedUC, urothelial cell cancerUPR, unfold protein responseUSA, United States of AmericaWHO, World Health OrganizationWI, Wisconsinbladder cancercDNA, copy number desoxyribonucleic acidmRNA, messenger ribo nucleic acidn, numberns, not significantpTa, papillary non-invasive tumorspromoter methylations.e.m., standard error of the margintumor cell migrationtumor suppressor gene
主题词
老年人(Aged);细胞系, 肿瘤(Cell Line, Tumor);细胞运动(Cell Movement);CpG岛(CpG Islands);cAMP反应元件结合蛋白质(Cyclic AMP Response Element-Binding Protein);DNA甲基化(DNA Methylation);减量调节(Down-Regulation);后成说, 遗传(Epigenesis, Genetic);女(雌)性(Female);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);基因沉默(Gene Silencing);人类(Humans);男(雄)性(Male);神经组织蛋白质类(Nerve Tissue Proteins);启动区, 遗传(Promoter Regions, Genetic);参考值(Reference Values);丝氨酸内肽酶类(Serine Endopeptidases);膀胱肿瘤(Urinary Bladder Neoplasms)
DOI
10.4161/15592294.2014.988052
PMID
25625847
发布时间
2018-11-13
- 浏览36
Epigenetics
1626-40页
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