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Mechanisms and pathways of innate immune activation and regulation in health and cancer.

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第一作者: Jun,Cui
第一单位: a Key Laboratory of Gene Engineering of the Ministry of Education; State Key Laboratory of Biocontrol; School of Life Sciences ; Sun Yat-sen University ; Guangzhou , P. R. China.
作者单位: a Key Laboratory of Gene Engineering of the Ministry of Education; State Key Laboratory of Biocontrol; School of Life Sciences ; Sun Yat-sen University ; Guangzhou , P. R. China. [1]
关键词 AIM2, absent in melanoma 2ALRs, AIM2-like receptorsAMPK, AMP activated protein kinaseASC, apoptosis-associated speck-like protein containing a CARDAtg16L, autophagy related 16-likeBMM, bone marrow-derived macrophageCARD, caspase recruitment domainCDNs, cyclic dinucleotidesCLRs, C-type lectin receptorsCMV, cytomegalovirusCYLD, the familial cylindromatosis tumor suppressor geneDAMPs, danger-associated molecular patternsDCs, dendritic cellsDDX41, DEAD (Asp-Glu-Ala-Asp) box polypeptide 41ER, endoplasmic reticulumGBP5, guanylate-binding protein 5GSK3β, Glycogen synthase kinase 3βHCC, hepatocellular carcinomaIFI16, interferon, gamma-inducible protein 16IFN, interferonIKK, IkB kinaseIKKi, inducible IkB kinaseIRAK, interleukin-1 receptor-associated kinaseIRF, interferon regulatory factorKSHV, Kaposi's sarcoma-associated herpesvirusLBP, LPS-binding proteinLGP 2, laboratory of genetics and physiology 2LPS, lipopolysaccharideLRR, leucine-rich repeatLT, lethal toxinLUBAC, linear ubiquitin assembly complexMAVS, mitochondrial antiviral signaling proteinMDA5, melanoma differentiation-associated protein 5MDP, muramyl dipeptideMIB, mind bombMyD88, myeloid differentiation factor 88NAIPs, neuronal apoptosis inhibitory proteinsNEMO, NF-kB essential modulatorNLRs, Nod- like receptorsNOD, nucleotide-binding oligomerization domainNrdp1, neuregulin receptor degradation protein 1PAMPs, pathogen-associated molecular patternsPKC-d, protein kinase C deltaPKR, dsRNA-dependent protein kinasePRRsPRRs, pathogen recognition receptorsRACK1, receptor for activated C kinase 1RAUL, RTA-associated E3 ligaseRIG-I, retinoic acid-inducible gene 1RIP, receptor-interacting proteinRLRs, RIG-I-like receptorsROS, reactive oxygen speciesSARM, sterile a- and armadillo motif-containing proteinSIGIRR, single Ig IL-1-related receptorSOCS, suppressor of cytokine signalingSTING, stimulator of interferon geneTAK1, TGF-b-activating kinase 1TANK, TRAF family-member-associated NF-kB activatorTBK1, TANK binding kinase 1TIR, Toll IL-1 receptorTIRAP, TIR domain-containing adapter proteinTLRs, Toll-like receptorsTRAF, TNFR-associated factorTRAILR, tumor-necrosis factor-related apoptosis-inducing ligand receptorTRAM, TRIF-related adaptor moleculeTRIF, TIR domain-containing adaptor inducing IFN-bTRIMs, tripartite motif containing proteinsTRIP, TRAF-interacting proteinULK1, autophagy related serine threonine UNC-51- like kinasecDC, conventional dendritic cellcGAS, cyclic GMP-AMP synthasecIAP, cellular inhibitor of apoptosis proteincanceriE-DAP, g-D-glutamyl-meso-diaminopimelic acidinflammationinnate immunitypDC, plasmacytoid dendritic celltype I interferon
DOI 10.4161/21645515.2014.979640
PMID 25625930
发布时间 2018-11-13
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