A novel cytostatic form of autophagy in sensitization of non-small cell lung cancer cells to radiation by vitamin D and the vitamin D analog, EB 1089.
作者:
关键词
ACTB, actin, βAMPK, AMP activated protein kinaseANXA5, annexin A5ATG5, autophagy related 5AVO, acidic vesicular organellesBECN1, Beclin 1, autophagy-relatedBaf, bafilomycin A1FACS, fluorescence activating cell sortingGFP, green fluorescent protein; H2AFX/H2AX, H2A histone family, member XGLB, galactosidaseMAP1LC3/LC3, microtubule-associated protein 1 light chain 3NSCLCNSCLC, non-small cell lung cancerPI, propidium iodideSQSTM1, sequestosome 1TP53, tumor protein p53VDR, vitamin D (1, 25-dihydroxyvitamin D3) receptorWT, wild-type; LC3 and LC3-II acronyms have been used to indicate the LC3B and LC3BII isoforms respectivelyautophagycytoprotectivecytostaticradiationβ
主题词
抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);自噬(Autophagy);骨化三醇(Calcitriol);癌, 非小细胞肺(Carcinoma, Non-Small-Cell Lung);细胞系, 肿瘤(Cell Line, Tumor);DNA损伤(DNA Damage);人类(Humans);肺肿瘤(Lung Neoplasms);维生素D(Vitamin D)
DOI
10.4161/15548627.2014.993283
PMID
25629933
发布时间
2018-11-13
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Autophagy
2346-61页
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