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Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase.

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第一作者： Dimitrios,Gritzalis

第一单位： Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC H3A 0B8, Canada.

作者： Dimitrios,Gritzalis ^[1] ; Jaeok,Park ^[2] ; Wei,Chiu ^[1] ; Hyungjun,Cho ^[1] ; Yih-Shyan,Lin ^[1] ; Joris W,De Schutter ^[1] ; Cyrus M,Lacbay ^[1] ; Michal,Zielinski ^[2] ; Albert M,Berghuis ^[3] ; Youla S,Tsantrizos ^[4]

作者单位： Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC H3A 0B8, Canada. ^[1] Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler, Montreal, QC H3G 1Y6, Canada. ^[2] Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler, Montreal, QC H3G 1Y6, Canada; Department of Microbiology and Immunology, McGill University, 3775 Rue University, Montreal, QC H3A 2B4, Canada; Groupe de Recherche Axé sur la Structure des Protéines, McGill University, 3649 Promenade Sir William Osler, Montréal, QC H3G 0B1, Canada. ^[3] Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC H3A 0B8, Canada; Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler, Montreal, QC H3G 1Y6, Canada; Groupe de Recherche Axé sur la Structure des Protéines, McGill University, 3649 Promenade Sir William Osler, Montréal, QC H3G 0B1, Canada. Electronic address: youla.tsantrizos@mcgill.ca. ^[4]

关键词 Allosteric inhibitors Bisphosphonates Human FPPS