Preclinical Pharmacokinetics and In Vitro Metabolism of Asunaprevir (BMS-650032), a Potent Hepatitis C Virus NS3 Protease Inhibitor.-论文-万方医学网

作者： Kathleen W,Mosure ^[1] ; Jay O,Knipe ^[1] ; Marc,Browning ^[2] ; Vinod,Arora ^[3] ; Yue-Zhong,Shu ^[3] ; Thomas,Phillip ^[3] ; Fiona,Mcphee ^[4] ; Paul,Scola ^[5] ; Anand,Balakrishnan ^[1] ; Matthew G,Soars ^[1] ; Kenneth,Santone ^[1] ; Michael,Sinz ^[1]

作者单位： Department of Metabolism and Pharmacokinetics, Bristol-Myers Squibb, Wallingford, Connecticut. ^[1] Department of Bioanalytical Research, Bristol-Myers Squibb, Wallingford, Connecticut. ^[2] Department of Biotransformation, Bristol-Myers Squibb, Wallingford, Connecticut. ^[3] Department of Virology, Bristol-Myers Squibb, Wallingford, Connecticut. ^[4] Department of Medicinal Chemistry, Bristol-Myers Squibb, Wallingford, Connecticut. ^[5]

主题词动物(Animals);抗病毒药(Antiviral Agents);胆汁(Bile);生物利用度(Biological Availability);细胞色素P-450 CYP3A(Cytochrome P-450 CYP3A);狗(Dogs);肝炎病毒属(Hepacivirus);肝细胞(Hepatocytes);人类(Humans);异喹啉类(Isoquinolines);肝(Liver);成束猴(Macaca fascicularis);男(雄)性(Male);小鼠(Mice);微粒体, 肝(Microsomes, Liver);氧化还原(Oxidation-Reduction);蛋白酶抑制药(Protease Inhibitors);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);磺胺类(Sulfonamides);病毒非结构蛋白质类(Viral Nonstructural Proteins)

DOI 10.1002/jps.24356

PMID 25631585

发布时间 2018-12-02

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Preclinical Pharmacokinetics and In Vitro Metabolism of Asunaprevir (BMS-650032), a Potent Hepatitis C Virus NS3 Protease Inhibitor.

Journal of pharmaceutical sciences

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Preclinical Pharmacokinetics and In Vitro Metabolism of Asunaprevir (BMS-650032), a Potent Hepatitis C Virus NS3 Protease Inhibitor.

Journal of pharmaceutical sciences

相似文献

Journal of pharmaceutical sciences

相关期刊

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