首页> The Journal of biological chemistry> Prolyl-4-hydroxylase domain protein 2 controls NF-κB/p65 transactivation and enhances the catabolic effects of inflammatory cytokines on cells of the nucleus pulposus.

Prolyl-4-hydroxylase domain protein 2 controls NF-κB/p65 transactivation and enhances the catabolic effects of inflammatory cytokines on cells of the nucleus pulposus.

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第一作者： Jun,Li

第一单位： From the Department of Orthopaedic Surgery and the Department of Orthopaedic Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.

作者： Jun,Li ^[1] ; Wen,Yuan ^[2] ; Shuai,Jiang ^[2] ; Wei,Ye ^[3] ; Hao,Yang ^[4] ; Irving M,Shapiro ^[5] ; Makarand V,Risbud ^[6]

作者单位： From the Department of Orthopaedic Surgery and the Department of Orthopaedic Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China. ^[1] the Department of Orthopaedic Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China. ^[2] From the Department of Orthopaedic Surgery and the Department of Orthopaedic Surgery, Sun Yat-sen Memorial Hospital of Sun Yat-Sen University, Guangzhou 510120, China, and. ^[3] From the Department of Orthopaedic Surgery and the Department of Orthopaedics, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China. ^[4] From the Department of Orthopaedic Surgery and the Graduate Program in Cell and Developmental Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, 19107. ^[5] From the Department of Orthopaedic Surgery and the Graduate Program in Cell and Developmental Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, 19107, makarand.risbud@jefferson.edu. ^[6]

关键词 Cytokine Action Hypoxia-inducible Factor (HIF)Intervertebral Disc NF-kappa B (NF-KB)Nucleus Pulposus Prolyl Hydroxylase Tumor Necrosis Factor (TNF)