换一批Post-translationally abnormal collagens of prolyl 3-hydroxylase-2 null mice offer a pathobiological mechanism for the high myopia linked to human LEPREL1 mutations.
第一作者：
David M,Hudson
第一单位：
From the Department of Orthopaedics and Sports Medicine, University of Washington, Seattle, Washington 98195 and.
作者：
医学主题词
氨基酸序列(Amino Acid Sequence);动物(Animals);胶原Ⅰ型(Collagen Type I);胶原Ⅳ型(Collagen Type IV);角膜(Cornea);疾病遗传易感性(Genetic Predisposition to Disease);人类(Humans);羟基化(Hydroxylation);晶体囊(Lens Capsule, Crystalline);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);分子序列数据(Molecular Sequence Data);突变(Mutation);近视(Myopia);器官特异性(Organ Specificity);表型(Phenotype);溶胶原脯氨酸二氧酶(Procollagen-Proline Dioxygenase);蛋白质加工, 转译后(Protein Processing, Post-Translational);巩膜(Sclera)
DOI
10.1074/jbc.M114.634915
PMID
25645914
发布时间
2021-02-05
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