换一批
换一批Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization.
作者：
关键词
ARG1, arginase 1BMDM, bone marrow-derived macrophagesCCL, chemokine (C-C motif) ligandCD, chow dietCHIL3/CHI3L3, chitinase-like 3GAPDH, glyceraldehyde-3-phosphate dehydrogenaseGFP, green fluorescent proteinGPT, glutamic pyruvic transaminase, solubleHFD, high-fat dietIFNG, interferon gammaIL, interleukinKupffer cellsLPS, lipopolysaccharideMAP1LC3/LC3B, microtubule-associated protein 1 light chain 3 βMAPK, mitogen-activated protein kinaseMGL2, macrophage galactose N-acetyl-galactosamine specific lectin 2NOS2, nitric oxide synthase 2, induciblePBS, phosphate-buffered salinePTGS2, prostaglandin-endoperoxide synthase 2RETNLA, resistin like α;STAT, signal transducer and activator of transcriptionTNF, tumor necrosis factorTUNEL, terminal deoxynucleotide transferase-mediated deoxyuridine triphosphate nick end-labelingWAT, white adipose tissueautophagyinnate immunitylipopolysaccharidemacrophageobesitypolarizationqRT-PCR, quantitative real-time PCRsteatohepatitis
主题词
脂肪组织(Adipose Tissue);动物(Animals);自噬(Autophagy);细胞极性(Cell Polarity);疾病模型, 动物(Disease Models, Animal);炎症(Inflammation);肝(Liver);巨噬细胞(Macrophages);小鼠, 基因敲除(Mice, Knockout);小鼠, 肥胖(Mice, Obese);肥胖症(Obesity);信号传导(Signal Transduction)
DOI
10.1080/15548627.2015.1009787
PMID
25650776
发布时间
2022-04-10
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Autophagy
271-84页
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