Quantitative proteomics reveals the downregulation of GRB2 as a prominent node of F806-targeted cell proliferation network.

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第一作者： Li-Yan,Li

第一单位： The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College, Shantou, Guangdong, PR China; Institute of Oncologic Pathology, Shantou University Medical College, Shantou, Guangdong, PR China.

作者： Li-Yan,Li ^[1] ; Kai,Zhang ^[2] ; Hong,Jiang ^[3] ; Yang-Min,Xie ^[4] ; Lian-Di,Liao ^[1] ; Bo,Chen ^[1] ; Ze-Peng,Du ^[1] ; Pi-Xian,Zhang ^[5] ; Hong,Chen ^[3] ; Wei,Huang ^[3] ; Wei,Jia ^[3] ; Hui-Hui,Cao ^[1] ; Wei,Zheng ^[6] ; En-Min,Li ^[7] ; Li-Yan,Xu ^[8]

作者单位： The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College, Shantou, Guangdong, PR China; Institute of Oncologic Pathology, Shantou University Medical College, Shantou, Guangdong, PR China. ^[1] Tianjin Key Laboratory of Medical Epigenetics, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, PR China. ^[2] Fujian Provincial Key Laboratory of Screening for Novel Microbial Products, Fujian Institute of Microbiology, Fuzhou, Fujian, PR China. ^[3] Experimental Animal Center, Shantou University Medical College, Shantou, Guangdong, PR China. ^[4] The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College, Shantou, Guangdong, PR China; Department of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou, Guangdong, PR China. ^[5] Fujian Provincial Key Laboratory of Screening for Novel Microbial Products, Fujian Institute of Microbiology, Fuzhou, Fujian, PR China. Electronic address: 13950399863@139.com. ^[6] The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College, Shantou, Guangdong, PR China; Department of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou, Guangdong, PR China. Electronic address: nmli@stu.edu.cn. ^[7] The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College, Shantou, Guangdong, PR China; Institute of Oncologic Pathology, Shantou University Medical College, Shantou, Guangdong, PR China. Electronic address: lyxu@stu.edu.cn. ^[8]

关键词 Cancer cell GRB2 Macrolide analog F806 Proteomics SILAC