Cell-based assay for low- and high-scale screening of the Wnt/β-catenin signaling modulators.

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第一作者： Maria,Mazur

第一单位： Innovative Drugs R&D Department, Celon Pharma, 05-092 Lomianki/Kielpin, Poland; Department of Molecular Cancerogenesis, Medical University of Lodz, 90-419 Lodz, Poland. Electronic address: maria.genowefa.mazur@gmail.com.

作者： Maria,Mazur ^[1] ; Anna,Bujak ^[2] ; Mikolaj,Matloka ^[2] ; Sylwia,Janowska ^[3] ; Pawel,Gunerka ^[4] ; Lukasz,Bojarski ^[3] ; Aleksandra,Stanczak ^[3] ; Agata,Klejman ^[5] ; Andrzej,Bednarek ^[6] ; Monika,Lamparska-Przybysz ^[3] ; Maciej,Wieczorek ^[3]

作者单位： Innovative Drugs R&D Department, Celon Pharma, 05-092 Lomianki/Kielpin, Poland; Department of Molecular Cancerogenesis, Medical University of Lodz, 90-419 Lodz, Poland. Electronic address: maria.genowefa.mazur@gmail.com. ^[1] Innovative Drugs R&D Department, Celon Pharma, 05-092 Lomianki/Kielpin, Poland; Postgraduate School of Molecular Medicine, 02-091 Warsaw, Poland. ^[2] Innovative Drugs R&D Department, Celon Pharma, 05-092 Lomianki/Kielpin, Poland. ^[3] Innovative Drugs R&D Department, Celon Pharma, 05-092 Lomianki/Kielpin, Poland; Department of Medical Biotechnology, Medical University of Lodz, 90-419 Lodz, Poland. ^[4] Laboratory of Animal Models, Nencki Institute, 02-093 Warsaw, Poland. ^[5] Department of Molecular Cancerogenesis, Medical University of Lodz, 90-419 Lodz, Poland. ^[6]

关键词 Alzheimer’s disease GSK-3 inhibitor High-throughput screening Luciferase reporter cell line Wnt/β-catenin signaling

主题词生物学鉴定法(Biological Assay);细胞系, 肿瘤(Cell Line, Tumor);药物评价, 临床前(Drug Evaluation, Preclinical);糖原合成酶激酶3(Glycogen Synthase Kinase 3);人类(Humans);TCF转录因子类(TCF Transcription Factors);β连环素(beta Catenin)

DOI 10.1016/j.ab.2015.01.016

PMID 25659657

发布时间 2015-04-14

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准确一般字义偏差语意偏离译文作用小提交