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Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis.

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第一作者: Jonathan D,Rohrer
第一单位: Dementia Research Centre, University College London, London, UK.
作者单位: Dementia Research Centre, University College London, London, UK. [1] Dementia Research Centre, University College London, London, UK; Department of Medical Statistics, London School of Hygiene & Tropical Medicine, London, UK. [2] Dementia Research Centre, University College London, London, UK; Department of Neurodegenerative Disease, University College London Institute of Neurology, and Centre for Medical Image Computing, University College London, London, UK. [3] Department of Neurology, Erasmus Medical Center, Rotterdam, Netherlands. [4] Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, Netherlands. [5] Institute of Psychology, Leiden University, and Department of Radiology, Leiden University Medical Center, Leiden, Netherlands. [6] Medical Research Council Prion Unit, University College London, London, UK. [7] Dementia Research Centre, University College London, London, UK; Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, University College London, London, UK. [8] Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, University College London, London, UK; Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, UK. [9] LC Campbell Cognitive Neurology Research Unit, Department of Medicine, Division of Neurology, Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada. [10] Department of Medicine, Division of Neurology, Baycrest, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada; Rotman Research Institute, Baycrest, Toronto, ON, Canada. [11] University Health Network Memory Clinic, Toronto Western Hospital, Toronto, ON, Canada. [12] Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada. [13] Clinique Interdisciplinaire de Mémoire, Département des Sciences Neurologiques, Hôpital de l'Enfant-Jésus, and Faculté de Médecine, Université Laval, QC, Canada. [14] Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologico Carlo Besta, Milano, Italy. [15] Neurology Unit, Department of Medical and Experimental Sciences, University of Brescia, Brescia, Italy. [16] Neurology Unit, Department of Physiopathology and Transplantation, University of Milan, Fondazione Cà Granda, Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Policlinico, Milan, Italy. [17] Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. [18] Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Huddinge, Sweden; Department of Geriatric Medicine, Karolinska University Hospital-Huddinge, Stockholm, Sweden. [19] Department of Geriatric Medicine, Karolinska University Hospital-Huddinge, Stockholm, Sweden. [20] Division of Clinical Geriatrics, Karolinska Institutet, Huddinge, Sweden; Department of Geriatric Medicine, Karolinska University Hospital-Huddinge, Stockholm, Sweden. [21] Department of Clinical Neuroscience, Karolinska Institutet, Huddinge, Sweden; Department of Psychology, Karolinska University Hospital-Huddinge, Stockholm, Sweden. [22] Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Huddinge, Sweden. [23] Istituto di Ricovero e Cura a Carattere Scientifico Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy; Memory Clinic and LANVIE-Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland. [24] Istituto di Ricovero e Cura a Carattere Scientifico Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy. [25] Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy; Istituto di Ricovero e Cura a Carattere Scientifico Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy. [26] Department of Clinical Neurological Sciences, University of Western Ontario, London, ON, Canada. [27] Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy. [28] Department of Clinical Pathophysiology, Nuclear Medicine Division, University of Florence, Florence, Italy. [29] Dementia Research Centre, University College London, London, UK. Electronic address: m.rossor@ucl.ac.uk. [30]
DOI 10.1016/S1474-4422(14)70324-2
PMID 25662776
发布时间 2025-05-29
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The Lancet. Neurology

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