PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease.-论文-万方医学网

第一作者： Gary W,Beecham

第一单位： From the John P. Hussman Institute for Human Genomics (G.W.B., W.K.S., E.R.M., K.N., L.W., D.M.D., M.A.P.-V., J.M.V.) and University of Miami Brain Endowment Bank (D.C.M.), Miller School of Medicine, University of Miami, FL; Departments of Neuroscience (D.W.D., O.A.R.) and Neurology (Z.K.W.), Mayo Clinic Florida, Jacksonville; Department of Pathology & Laboratory Medicine (G.S., J.Q.T., V.M.V.D., H.I.H.), Perelman School of Medicine, Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia; Group Health Research Institute (E.B.L.), Seattle, WA; Departments of Psychiatry, and Genetics and Genomic Sciences (J.D.B.), Mount Sinai School of Medicine, New York, NY; Arizona Alzheimer's Consortium (T.G.B.), Phoenix; Sun Health Research Institute (T.G.B.), Sun City, AZ; Division of Neuropathology, Department of Pathology (J.C.T., O.P.), and Department of Neurology and the Solomon H. Snyder Department of Neuroscience (T.M.D.), Johns Hopkins University School of Medicine, Baltimore, MD; Kubik Laboratory for Neuropathology (M.P.F.), Massachusetts General Hospital and Harvard Medical School, Charlestown, MA; Department of Pathology and Laboratory Medicine, Indiana Alzheimer Disease Center (B.G.), and Department of Medical and Molecular Genetics (T.M.F.), Indiana University School of Medicine, Indianapolis; Departments of Neurology (L.S.H., K.M.) and Psychiatry (K.M.), Gertrude H. Sergievsky Center, and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York; Department of Pathology and Cell Biology (J.P.V.), Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York, NY; The Parkinson's Institute (S.M.G.), Sunnyvale, CA; Departments of Pathology and Laboratory Medicine (Neuropathology) and Neurology (H.V.V.), David Geffen School of Medicine at University of California Los Angeles; Department of Pathology (T.J.M.), University of Washington School of Medicine, Seattle; VA Puget Sound Health Care System (

作者： Gary W,Beecham ^[1] ; Dennis W,Dickson ^[1] ; William K,Scott ^[1] ; Eden R,Martin ^[1] ; Gerard,Schellenberg ^[1] ; Karen,Nuytemans ^[1] ; Eric B,Larson ^[1] ; Joseph D,Buxbaum ^[1] ; John Q,Trojanowski ^[1] ; Vivianna M,Van Deerlin ^[1] ; Howard I,Hurtig ^[1] ; Deborah C,Mash ^[1] ; Thomas G,Beach ^[1] ; Juan C,Troncoso ^[1] ; Olga,Pletnikova ^[1] ; Matthew P,Frosch ^[1] ; Bernardino,Ghetti ^[1] ; Tatiana M,Foroud ^[1] ; Lawrence S,Honig ^[1] ; Karen,Marder ^[1] ; Jean Paul,Vonsattel ^[1] ; Samuel M,Goldman ^[1] ; Harry V,Vinters ^[1] ; Owen A,Ross ^[1] ; Zbigniew K,Wszolek ^[1] ; Liyong,Wang ^[1] ; Derek M,Dykxhoorn ^[1] ; Margaret A,Pericak-Vance ^[1] ; Thomas J,Montine ^[1] ; James B,Leverenz ^[1] ; Ted M,Dawson ^[1] ; Jeffery M,Vance ^[1]

作者单位： From the John P. Hussman Institute for Human Genomics (G.W.B., W.K.S., E.R.M., K.N., L.W., D.M.D., M.A.P.-V., J.M.V.) and University of Miami Brain Endowment Bank (D.C.M.), Miller School of Medicine, University of Miami, FL; Departments of Neuroscience (D.W.D., O.A.R.) and Neurology (Z.K.W.), Mayo Clinic Florida, Jacksonville; Department of Pathology & Laboratory Medicine (G.S., J.Q.T., V.M.V.D., H.I.H.), Perelman School of Medicine, Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia; Group Health Research Institute (E.B.L.), Seattle, WA; Departments of Psychiatry, and Genetics and Genomic Sciences (J.D.B.), Mount Sinai School of Medicine, New York, NY; Arizona Alzheimer's Consortium (T.G.B.), Phoenix; Sun Health Research Institute (T.G.B.), Sun City, AZ; Division of Neuropathology, Department of Pathology (J.C.T., O.P.), and Department of Neurology and the Solomon H. Snyder Department of Neuroscience (T.M.D.), Johns Hopkins University School of Medicine, Baltimore, MD; Kubik Laboratory for Neuropathology (M.P.F.), Massachusetts General Hospital and Harvard Medical School, Charlestown, MA; Department of Pathology and Laboratory Medicine, Indiana Alzheimer Disease Center (B.G.), and Department of Medical and Molecular Genetics (T.M.F.), Indiana University School of Medicine, Indianapolis; Departments of Neurology (L.S.H., K.M.) and Psychiatry (K.M.), Gertrude H. Sergievsky Center, and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York; Department of Pathology and Cell Biology (J.P.V.), Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York, NY; The Parkinson's Institute (S.M.G.), Sunnyvale, CA; Departments of Pathology and Laboratory Medicine (Neuropathology) and Neurology (H.V.V.), David Geffen School of Medicine at University of California Los Angeles; Department of Pathology (T.J.M.), University of Washington School of Medicine, Seattle; VA Puget Sound Health Care System ( ^[1]

主题词老年人(Aged);老年人, 80以上(Aged, 80 and over);染色体, 人, 1对(Chromosomes, Human, Pair 1);女(雌)性(Female);基因座(Genetic Loci);全基因组关联研究(Genome-Wide Association Study);人类(Humans);连锁不平衡(Linkage Disequilibrium);男(雄)性(Male);帕金森病(Parkinson Disease);多态性, 单核苷酸(Polymorphism, Single Nucleotide)

DOI 10.1212/WNL.0000000000001332

PMID 25663231

发布时间 2022-05-18

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PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease.

Neurology

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PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease.

Neurology

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Neurology

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