A multi-organ chip co-culture of neurospheres and liver equivalents for long-term substance testing.

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作者： Eva-Maria,Materne ^[1] ; Anja Patricia,Ramme ^[2] ; Ana Paula,Terrasso ^[3] ; Margarida,Serra ^[4] ; Paula Marques,Alves ^[5] ; Catarina,Brito ^[6] ; Dmitry A,Sakharov ^[7] ; Alexander G,Tonevitsky ^[8] ; Roland,Lauster ^[9] ; Uwe,Marx ^[10]

作者单位： Technische Universität Berlin, Institute of Biotechnology, Gustav-Meyer-Allee 25, Berlin 13355, Germany. Electronic address: eva-maria.materne@tu-berlin.de. ^[1] Technische Universität Berlin, Institute of Biotechnology, Gustav-Meyer-Allee 25, Berlin 13355, Germany. Electronic address: anja.ramme@tu-berlin.de. ^[2] iBET, Instituto de Biologia Experimental e Tecnológica, Oeiras 2780-901, Portugal; ITQB-UNL, Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, 2780-157 Oeiras, Portugal. Electronic address: aterrasso@itqb.unl.pt. ^[3] iBET, Instituto de Biologia Experimental e Tecnológica, Oeiras 2780-901, Portugal; ITQB-UNL, Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, 2780-157 Oeiras, Portugal. Electronic address: mserra@ibet.pt. ^[4] iBET, Instituto de Biologia Experimental e Tecnológica, Oeiras 2780-901, Portugal; ITQB-UNL, Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, 2780-157 Oeiras, Portugal. Electronic address: marques@ibet.pt. ^[5] iBET, Instituto de Biologia Experimental e Tecnológica, Oeiras 2780-901, Portugal; ITQB-UNL, Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, 2780-157 Oeiras, Portugal. Electronic address: anabrito@itqb.unl.pt. ^[6] Scientific Research Centre Bioclinicum, Ugreshskaya ul. 2/85, 115088 Moscow, Russia. Electronic address: dimitri_sakharov@mail.ru. ^[7] Institute of General Pathology and Pathophysiology, Russian Academy of Medical Science, Baltiyskaya ul. 8, 125315 Moscow, Russia. Electronic address: tonevitsky@mail.ru. ^[8] Technische Universität Berlin, Institute of Biotechnology, Gustav-Meyer-Allee 25, Berlin 13355, Germany. Electronic address: roland.lauster@tu-berlin.de. ^[9] Technische Universität Berlin, Institute of Biotechnology, Gustav-Meyer-Allee 25, Berlin 13355, Germany; TissUse GmbH, Markgrafenstr. 18, 15528 Spreenhagen, Germany. Electronic address: uwe.marx@tu-berlin.de. ^[10]

关键词 In vitro substance testing Liver Multi-organ-chip Neurospheres Organoids Tissue engineering