换一批Efficacy and safety of the hypoxia-activated prodrug TH-302 in combination with gemcitabine and nab-paclitaxel in human tumor xenograft models of pancreatic cancer.
第一作者：
Jessica D,Sun
第一单位：
a Threshold Pharmaceuticals , South San Francisco , CA , USA.
作者：
关键词
BW, body weightBr-IPM, a brominated analog of isophosphoramide mustardCAF, cancer-associated fibroblastCAIX, carbonic anhydrase IXCR, complete responseEMT, epithelial to mesenchymal transitionG, gemcitabineHF, hypoxic fractionILS, increased life spanMT, median time to reach the size of 1000?mm3MTD, maximum tolerated doseNF, necrotic fractionPDAC, pancreatic ductal adenocarcinomaT, TH-302TGD1000, tumor growth delay compared to Vehicle reaching the size of 1000?mm3TGI, tumor growth inhibitionTH-302V, vehiclegemcitabinehypoxiahypoxia-activated prodrugnP, nab-paclitaxelnab-paclitaxelpancreatic cancerpharmacodynamics, biomarkersmooth muscle actinxenograftα-SMA, α
主题词
白蛋白类(Albumins);动物(Animals);抗肿瘤联合化疗方案(Antineoplastic Combined Chemotherapy Protocols);细胞凋亡(Apoptosis);癌, 胰腺管(Carcinoma, Pancreatic Ductal);细胞低氧(Cell Hypoxia);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);DNA损伤(DNA Damage);脱氧胞苷(Deoxycytidine);人类(Humans);小鼠(Mice);硝基咪唑类(Nitroimidazoles);紫杉酚(Paclitaxel);磷酸酰胺氮芥类(Phosphoramide Mustards);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1080/15384047.2014.1003005
PMID
25679067
发布时间
2022-12-07
- 浏览103
Cancer biology & therapy
438-49页
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